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Appl. Sci. 2017, 7(3), 287;

Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats

Department of Anesthesiology and Intensive Care Medicine, Clinical Sensoring and Monitoring, Faculty of Medicine CGC, Technische Universität Dresden, Dresden 01307, Germany
InfraTec GmbH, Gostritzer Straße 61-63, Dresden 01217, Germany
Author to whom correspondence should be addressed.
Academic Editor: Michael Pircher
Received: 19 January 2017 / Revised: 8 March 2017 / Accepted: 10 March 2017 / Published: 15 March 2017
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography (OCT))
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Though artificial ventilation is an essential life-saving treatment, the mechanical behavior of lung tissue at the alveolar level is still unknown. Therefore, we need to understand the tissue response during artificial ventilation at this microscale in order to develop new and more protective ventilation methods. Optical coherence tomography (OCT) combined with intravital microscopy (IVM) is a promising tool for visualizing lung tissue dynamics with a high spatial and temporal resolution in uninterruptedly ventilated rats. We present a measurement setup using a custom-made animal ventilator and a gating technique for data acquisition of time-resolved sequences. View Full-Text
Keywords: optical coherence tomography; OCT; mechanical ventilation; lung imaging optical coherence tomography; OCT; mechanical ventilation; lung imaging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Schnabel, C.; Gaertner, M.; Koch, E. Optical Coherence Tomography (OCT) for Time-Resolved Imaging of Alveolar Dynamics in Mechanically Ventilated Rats. Appl. Sci. 2017, 7, 287.

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