Review Reports

Round 1

Reviewer 1 Report

The manuscript from Juloski and colleagues explore correlation between  orthodontic pain and analgesics consumption, through aiming to investigate predictive factors. The manuscript is well organized and well written.

This reviewer's only concern is about sample size: how was it calculated?

Author Response

This reviewer's only concern is about sample size: how was it calculated?

Dear reviewer,

According to the sample size calculations, it was presumed that a sample of at least 220 patients should be enrolled in the study having in mind that sample size should be 10 times greater than number of independent variables, which was 22 in this study. According to Bujang et al., "Sample size guidelines for logistic regression from observational studies with large population: emphasis on the accuracy between statistics and parameters based on real life clinical data." MJMS 25.4 (2018): 122. recommended sample size using rules of thumb with formula EPV=100+50*i, where i stands for independent variables in the final model, we had 3 independent variables in the final model so our sample size is set on 250 patients. 

Reviewer 2 Report

Please in the limitation of the study also include different wires that are used.

Author Response

Please in the limitation of the study also include different wires that are used.

Dear reviewer,

we included information about different initial archwire size in the limitations of the study, and that it can not be completely controlled having in mind different malocclusions and initial crowding in patients enrolled in our study.