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Review

Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy

LAQV/REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal
*
Author to whom correspondence should be addressed.
Present address: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, Portugal.
Appl. Sci. 2020, 10(24), 8990; https://doi.org/10.3390/app10248990
Received: 23 November 2020 / Revised: 5 December 2020 / Accepted: 11 December 2020 / Published: 16 December 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
This review deals with the various aspects involved in the medicinal action of curcumin, from the photosensitivity and its relevance to storage and shelf-life, to the different routes of administration, which influence the bioavailability. The focus of the review is on the antitumor properties of curcumin and the currently available solutions for their amelioration. The work starts by presenting a brief historical perspective on the origins and uses of curcumin, from early days until the present time. The following sections describe the physico-chemical properties of curcumin and their impact on the biological activity and pharmacokinetics, raising awareness to the need for formulations able to improve the bioavailability. The last section is focused on research efforts being made to circumvent curcumin’s instability and low availability due to the extensive hepatic first pass metabolism, describing innovative scientific advances and new patented formulations and emerging products on the market. View Full-Text
Keywords: cancer chemotherapy; clinical trials; bioavailability; dosage forms; encapsulation; metal complexes cancer chemotherapy; clinical trials; bioavailability; dosage forms; encapsulation; metal complexes
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MDPI and ACS Style

Carvalho Henriques, M.; Faustino, M.A.F.; Santos Braga, S. Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy. Appl. Sci. 2020, 10, 8990. https://doi.org/10.3390/app10248990

AMA Style

Carvalho Henriques M, Faustino MAF, Santos Braga S. Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy. Applied Sciences. 2020; 10(24):8990. https://doi.org/10.3390/app10248990

Chicago/Turabian Style

Carvalho Henriques, Magda, Maria Amparo F. Faustino, and Susana Santos Braga. 2020. "Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy" Applied Sciences 10, no. 24: 8990. https://doi.org/10.3390/app10248990

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