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Article

Platelet Rich STROMA, the Combination of PRP and tSVF and Its Potential Effect on Osteoarthritis of the Knee

1
PRSkliniek.nl, Rotterdam-Vlaardingen, Churchillsingel 472, 3127 XB Vlaardingen, The Netherlands
2
Department of Plastic Surgery, University of Groningen and University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
3
Bergman Clinics, 4817 BL Breda, The Netherlands
*
Author to whom correspondence should be addressed.
Shared first author.
Appl. Sci. 2020, 10(14), 4691; https://doi.org/10.3390/app10144691
Received: 30 May 2020 / Revised: 3 July 2020 / Accepted: 6 July 2020 / Published: 8 July 2020
(1) Background: osteoarthritis (OA) of the knee is a degenerative disease accompanied by pain, reduced mobility and subsequent decrease in quality of life. Many studies on OA of the knee have reported that using an intercellular acting-derivate like platelet-rich plasma (PRP) results in a limited effect or none at all. Authors hypothesized that adding tissue-Stromal Vascular Fraction (tSVF) to PRP (Platelet Rich Stroma (PRS)) would reduce pain and improve functionality in osteoarthritis of the knee. (2) Methods: a consecutive case series of fifteen patients (aged 43–75 years) suffering from OA of the knee (Kellgren–Lawrence stage two to three) were treated with a single injection of autologous PRS. tSVF was mechanically isolated by means of the fractionation of adipose tissue (FAT) procedure. Clinical evaluation was done using a visual analogue score (VAS) score, an adapted Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and Lysholm score at fixed time points: pre-injection as well as three, six and twelve months post injection. (3) Results: VAS and WOMAC scores improved significantly after twelve months (p < 0.01 and p < 0.05). Lysholm instability scores were also improved at twelve months (p > 0.05) in comparison to pre-injection measurements. No complications were seen in any of the patients. One patient was excluded due to a total knee arthroplasty. (4) Conclusions: a single injection with PRS for OA of the knee seems to lead to an improvement of function and simultaneous reduction of pain and joint stiffness for a period of twelve months. Further controlled trials are required to determine the optimal treatment regimen and evaluate long-term results. View Full-Text
Keywords: SVF; PRP; knee osteoarthritis; regenerative SVF; PRP; knee osteoarthritis; regenerative
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MDPI and ACS Style

Stevens, H.P.; van Boxtel, J.; van Dijck, R.; van Dongen, J.A. Platelet Rich STROMA, the Combination of PRP and tSVF and Its Potential Effect on Osteoarthritis of the Knee. Appl. Sci. 2020, 10, 4691. https://doi.org/10.3390/app10144691

AMA Style

Stevens HP, van Boxtel J, van Dijck R, van Dongen JA. Platelet Rich STROMA, the Combination of PRP and tSVF and Its Potential Effect on Osteoarthritis of the Knee. Applied Sciences. 2020; 10(14):4691. https://doi.org/10.3390/app10144691

Chicago/Turabian Style

Stevens, Hieronymus P., Joeri van Boxtel, Robbert van Dijck, and Joris A. van Dongen. 2020. "Platelet Rich STROMA, the Combination of PRP and tSVF and Its Potential Effect on Osteoarthritis of the Knee" Applied Sciences 10, no. 14: 4691. https://doi.org/10.3390/app10144691

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