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Med. Sci. 2018, 6(1), 4; https://doi.org/10.3390/medsci6010004

Role of Polyamines in Asthma Pathophysiology

1
Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi 110007, India
2
Academy of Scientific and Innovative Research (AcSIR), Chennai 600113, India
Received: 12 December 2017 / Revised: 31 December 2017 / Accepted: 2 January 2018 / Published: 6 January 2018
(This article belongs to the Special Issue Polyamine Metabolism in Disease and Polyamine-Targeted Therapies)
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Abstract

Asthma is a complex disease of airways, where the interactions of immune and structural cells result in disease outcomes with airway remodeling and airway hyper-responsiveness. Polyamines, which are small-sized, natural super-cations, interact with negatively charged intracellular macromolecules, and altered levels of polyamines and their interactions have been associated with different pathological conditions including asthma. Elevated levels of polyamines have been reported in the circulation of asthmatic patients as well as in the lungs of a murine model of asthma. In various studies, polyamines were found to potentiate the pathogenic potential of inflammatory cells, such as mast cells and granulocytes (eosinophils and neutrophils), by either inducing the release of their pro-inflammatory mediators or prolonging their life span. Additionally, polyamines were crucial in the differentiation and alternative activation of macrophages, which play an important role in asthma pathology. Importantly, polyamines cause airway smooth muscle contraction and thus airway hyper-responsiveness, which is the key feature in asthma pathophysiology. High levels of polyamines in asthma and their active cellular and macromolecular interactions indicate the importance of the polyamine pathway in asthma pathogenesis; therefore, modulation of polyamine levels could be a suitable approach in acute and severe asthma management. This review summarizes the possible roles of polyamines in different pathophysiological features of asthma. View Full-Text
Keywords: spermine; spermidine; putrescine; polyamine metabolism; mast cells; eosinophils; neutrophils; M2 macrophages; airway smooth muscle cells spermine; spermidine; putrescine; polyamine metabolism; mast cells; eosinophils; neutrophils; M2 macrophages; airway smooth muscle cells
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Jain, V. Role of Polyamines in Asthma Pathophysiology. Med. Sci. 2018, 6, 4.

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