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Pathogens, Volume 12, Issue 1

January 2023 - 149 articles

Cover Story: Chronic infection with the hepatitis B virus (HBV) affects an estimated 257 million people world-wide and can lead to serious diseases such as liver cirrhosis and hepatocellular carcinoma. HBV replication is not cytopathic, but some HBV proteins have direct carcinogenic effects. HBV-infected cells communicate with other cells, such as other hepatocytes, liver stromal cells, and innate and adaptive immune cells. They do so via both direct interaction and by secreting factors into their environment. Such factors may be small molecules, such as metabolites and viral and cellular proteins, but can also be more complex, such as virions, protein complexes, and extracellular vesicles. We review how the communication between the HBV-infected cells and cells in their environment forms a basis for viral persistence and HBV infection-related pathology. View this paper
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Articles (149)

  • Article
  • Open Access
13 Citations
3,081 Views
9 Pages

Reservoirs of Corynebacterium spp. in the Environment of Dairy Cows

  • Svenja Woudstra,
  • Anneke Lücken,
  • Nicole Wente,
  • Yanchao Zhang,
  • Stefanie Leimbach,
  • Maya Katrin Gussmann,
  • Carsten Kirkeby and
  • Volker Krömker

13 January 2023

Although Corynebacterium spp. can be regularly associated with subclinical and clinical mastitis cases in dairy cows, knowledge on their reservoirs in dairy farms is sparse. Therefore, samples were collected at 10 visits with 14 day intervals from be...

  • Review
  • Open Access
55 Citations
30,087 Views
15 Pages

13 January 2023

The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) v...

  • Article
  • Open Access
9 Citations
3,884 Views
13 Pages

Adaptive Evolution Compensated for the Plasmid Fitness Costs Brought by Specific Genetic Conflicts

  • Feifeng Li,
  • Jiong Wang,
  • Ying Jiang,
  • Yingyi Guo,
  • Ningjing Liu,
  • Shunian Xiao,
  • Likang Yao,
  • Jiahui Li,
  • Chuyue Zhuo and
  • Nanhao He
  • + 2 authors

13 January 2023

New Delhi metallo-β-lactamase (NDM)-carrying IncX3 plasmids is important in the transmission of carbapenem resistance in Escherichia coli. Fitness costs related to plasmid carriage are expected to limit gene exchange; however, the causes of these fit...

  • Article
  • Open Access
6 Citations
3,571 Views
22 Pages

Selene-Ethylenelacticamides and N-Aryl-Propanamides as Broad-Spectrum Leishmanicidal Agents

  • Natália Ferreira de Sousa,
  • Helivaldo Diógenes da Silva Souza,
  • Renata Priscila Barros de Menezes,
  • Francinara da Silva Alves,
  • Chonny Alexander Herrera Acevedo,
  • Thaís Amanda de Lima Nunes,
  • Zoe L. Sessions,
  • Luciana Scotti,
  • Eugene N. Muratov and
  • Francisco Jaime Bezerra Mendonça-Junior
  • + 3 authors

13 January 2023

The World Health Organization classifies Leishmania as one of the 17 “neglected diseases” that burden tropical and sub-tropical climate regions with over half a million diagnosed cases each year. Despite this, currently available anti-lei...

  • Article
  • Open Access
1 Citations
2,857 Views
12 Pages

Leptospira interrogans Serovar Icterohaemorrhagiae Failed to Establish Distinct Infection in Naïve Gilts: Lessons Learned from a Preliminary Experimental Challenge

  • Romana Steinparzer,
  • Sophie Duerlinger,
  • Friedrich Schmoll,
  • Adi Steinrigl,
  • Zoltán Bagó,
  • Denise Willixhofer,
  • Osaid Al Salem,
  • Sarolta Takács,
  • Christian Knecht and
  • René Renzhammer
  • + 3 authors

13 January 2023

Leptospira is a pathogen involved in fertility problems in pigs. Nevertheless, little information is available on pathogenicity, transmission, tissue tropism, and immune response. The objective of this preliminary study was to induce a diagnostically...

  • Article
  • Open Access
8 Citations
2,314 Views
13 Pages

Survey and Molecular Characterization of Echinococcus granulosus sensu stricto from Livestock and Humans in the Altai Region of Xinjiang, China

  • Baoping Guo,
  • Li Zhao,
  • Lu Zhao,
  • Rongsheng Mi,
  • Xu Zhang,
  • Bingjie Wang,
  • Gang Guo,
  • Yuan Ren,
  • Wenjing Qi and
  • Zhuangzhi Zhang

13 January 2023

Cystic echinococcosis (CE), caused by the metacestode Echinococcus granulosus sensu stricto (s.s.), is an important zoonotic parasite, endemic in the Altai region of China. It is a serious human health risk and causes livestock losses. To evalua...

  • Review
  • Open Access
19 Citations
10,598 Views
19 Pages

Cytauxzoon felis: An Overview

  • Yvonne M. Wikander and
  • Kathryn E. Reif

13 January 2023

Cytauxzoon felis is a tick-transmitted, obligate, hemoprotozoal, piroplasmid pathogen of felids and the causative agent of cytauxzoonosis. It has a complex life cycle which includes a tick as its definitive host and a felid as its intermediate host....

  • Review
  • Open Access
15 Citations
7,219 Views
26 Pages

An Inventory of Anthelmintic Plants across the Globe

  • Haroon Ahmed,
  • Seyma Gunyakti Kilinc,
  • Figen Celik,
  • Harun Kaya Kesik,
  • Sami Simsek,
  • Khawaja Shafique Ahmad,
  • Muhammad Sohail Afzal,
  • Sumaira Farrakh,
  • Waseem Safdar and
  • Fahad Pervaiz
  • + 3 authors

13 January 2023

A wide range of novelties and significant developments in the field of veterinary science to treat helminth parasites by using natural plant products have been assessed in recent years. To the best of our knowledge, to date, there has not been such a...

  • Article
  • Open Access
7 Citations
4,367 Views
12 Pages

Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding

  • Sukanya Narasimhan,
  • Carmen J. Booth,
  • Mario T. Philipp,
  • Erol Fikrig and
  • Monica E. Embers

13 January 2023

The blacklegged tick, Ixodes scapularis, is the predominant vector of Borrelia burgdorferi, the agent of Lyme disease in the USA. Natural hosts of I. scapularis such as Peromyscus leucopus are repeatedly infested by these ticks without acquiring tick...

  • Article
  • Open Access
5 Citations
2,469 Views
10 Pages

12 January 2023

Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis. However, the propagation and distribution of BLV after primary infection still need to be fully elucidated. Here, we experimentally infected seven cattle with BLV and a...

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Pathogens - ISSN 2076-0817Creative Common CC BY license