Minimally Invasive Therapies for Knee Osteoarthritis

Osuala, Uchenna; Goh, Megan H.; Mansur, Arian; Smirniotopoulos, John B.; Scott, Arielle; Vassell, Christine; Yousefi, Bardia; Jain, Neil K.; Sag, Alan A.; Lax, Allison; Park, Kevin W.; Kheradi, Alexander; Sapoval, Marc; Golzarian, Jafar; Habibollahi, Peiman; Ahmed, Osman; Young, Shamar; Nezami, Nariman

doi:10.3390/jpm14090970

Open AccessEditor’s ChoiceReview

Minimally Invasive Therapies for Knee Osteoarthritis

by

Uchenna Osuala

¹

,

Megan H. Goh

²

,

Arian Mansur

²

,

John B. Smirniotopoulos

^1,3

,

Arielle Scott

⁴

,

Christine Vassell

⁴,

Bardia Yousefi

⁴

,

Neil K. Jain

³

,

Alan A. Sag

⁵,

Allison Lax

⁶,

Kevin W. Park

⁷,

Alexander Kheradi

⁸,

Marc Sapoval

⁹,

Jafar Golzarian

^10,11,

Peiman Habibollahi

¹²,

Osman Ahmed

¹³,

Shamar Young

¹⁴

and

Nariman Nezami

^1,15,16,*

¹

Georgetown University School of Medicine, Washington, DC 20007, USA

²

Harvard Medical School, Cambridge, MA 02115, USA

³

Division of Vascular and Interventional Radiology, MedStar Washington Hospital Center, Washington, DC 20010, USA

⁴

Department of Bioengineering, University of Maryland College Park, College Park, MD 20742, USA

⁵

Division of Vascular and Interventional Radiology, Department of Radiology, Duke University Medical Center, Durham, NC 27705, USA

⁶

Department of Radiology, MedStar Georgetown University Hospital, Washington, DC 20007, USA

⁷

Department of Orthopaedic Surgery, MedStar Georgetown University Hospital, Washington, DC 20007, USA

⁸

Department of Emergency Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, USA

⁹

Hôpital Européen Georges-Pompidou, 75015 Paris, France

¹⁰

North Star Vascular and Interventional Institute, Minnesota, MN 55427, USA

¹¹

Department of Radiology, Division of Vascular and Interventional Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA

¹²

Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

¹³

Division of Interventional Radiology, Rush University Medical Center, Chicago, IL 60612, USA

¹⁴

Division of Interventional Radiology, Department of Medical Imaging, University of Arizona Medical Center, Tucson, AZ 85712, USA

¹⁵

Division of Vascular and Interventional Radiology, MedStar Georgetown University Hospital, Washington, DC 20007, USA

¹⁶

Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA

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Author to whom correspondence should be addressed.

J. Pers. Med. 2024, 14(9), 970; https://doi.org/10.3390/jpm14090970

Submission received: 5 August 2024 / Revised: 4 September 2024 / Accepted: 6 September 2024 / Published: 13 September 2024

(This article belongs to the Special Issue Interventional Radiology and Personalized Medicine)

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Abstract

Knee osteoarthritis (KOA) is a musculoskeletal disorder characterized by articular cartilage degeneration and chronic inflammation, affecting one in five people over 40 years old. The purpose of this study was to provide an overview of traditional and novel minimally invasive treatment options and role of artificial intelligence (AI) to streamline the diagnostic process of KOA. This literature review provides insights into the mechanisms of action, efficacy, complications, technical approaches, and recommendations to intra-articular injections (corticosteroids, hyaluronic acid, and plate rich plasma), genicular artery embolization (GAE), and genicular nerve ablation (GNA). Overall, there is mixed evidence to support the efficacy of the intra-articular injections that were covered in this study with varying degrees of supported recommendations through formal medical societies. While GAE and GNA are more novel therapeutic options, preliminary evidence supports their efficacy as a potential minimally invasive therapy for patients with moderate to severe KOA. Furthermore, there is evidentiary support for the use of AI to assist clinicians in the diagnosis and potential selection of treatment options for patients with KOA. In conclusion, there are many exciting advancements within the diagnostic and treatment space of KOA.

Keywords: knee osteoarthritis; genicular artery embolization; genicular nerve ablation; regenerative and experimental therapies; AI for knee osteoarthritis

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MDPI and ACS Style

Osuala, U.; Goh, M.H.; Mansur, A.; Smirniotopoulos, J.B.; Scott, A.; Vassell, C.; Yousefi, B.; Jain, N.K.; Sag, A.A.; Lax, A.; et al. Minimally Invasive Therapies for Knee Osteoarthritis. J. Pers. Med. 2024, 14, 970. https://doi.org/10.3390/jpm14090970

AMA Style

Osuala U, Goh MH, Mansur A, Smirniotopoulos JB, Scott A, Vassell C, Yousefi B, Jain NK, Sag AA, Lax A, et al. Minimally Invasive Therapies for Knee Osteoarthritis. Journal of Personalized Medicine. 2024; 14(9):970. https://doi.org/10.3390/jpm14090970

Chicago/Turabian Style

Osuala, Uchenna, Megan H. Goh, Arian Mansur, John B. Smirniotopoulos, Arielle Scott, Christine Vassell, Bardia Yousefi, Neil K. Jain, Alan A. Sag, Allison Lax, and et al. 2024. "Minimally Invasive Therapies for Knee Osteoarthritis" Journal of Personalized Medicine 14, no. 9: 970. https://doi.org/10.3390/jpm14090970

APA Style

Osuala, U., Goh, M. H., Mansur, A., Smirniotopoulos, J. B., Scott, A., Vassell, C., Yousefi, B., Jain, N. K., Sag, A. A., Lax, A., Park, K. W., Kheradi, A., Sapoval, M., Golzarian, J., Habibollahi, P., Ahmed, O., Young, S., & Nezami, N. (2024). Minimally Invasive Therapies for Knee Osteoarthritis. Journal of Personalized Medicine, 14(9), 970. https://doi.org/10.3390/jpm14090970

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Minimally Invasive Therapies for Knee Osteoarthritis

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