Next Article in Journal
Learning Curve Analysis of Single-Incision Ovarian Cystectomy: Comparative Study of Robotic and Conventional Laparoscopic Techniques
Next Article in Special Issue
The Effects of Resistance Training on Pain, Strength, and Function in Osteoarthritis: Systematic Review and Meta-Analysis
Previous Article in Journal
Early Symptoms and Treatment Outcomes in Neuronal Ceroid Lipofuscinosis Type 2: Croatian Experience
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JPM
Volume 14
Issue 8
10.3390/jpm14080784
jpm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Retrospective Study

by
Domiziano Tarantino
1,*,
Alfonso Maria Forte
2,
Antonio Picone
1,
Felice Sirico
1 and
Carlo Ruosi
1
1
Department of Public Health, University of Naples Federico II, 80131 Naples, Italy
2
Biomedical Research Center, Gruppo Forte, 84124 Salerno, Italy
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2024, 14(8), 784; https://doi.org/10.3390/jpm14080784
Submission received: 1 July 2024 / Revised: 17 July 2024 / Accepted: 20 July 2024 / Published: 24 July 2024
(This article belongs to the Special Issue Progress on Personalized Diagnosis and Treatment of Osteoarthritis)
Browse Figures
Versions Notes

Abstract

Knee osteoarthritis (KOA) is a progressive and multifactorial disease that leads to joint pain, muscle weakness, physical disability, and decreased quality of life. In KOA, the quantity of hyaluronic acid (HA) and the molecular weight (MW) are decreased, leading to joint pain due to increased wear of the knee articular cartilage. Arthrogenic muscle inhibition, which is usually found in patients with KOA, is associated with joint inflammation, pain, and swelling, also causing muscle atrophy, primarily of the anterior thigh muscles, and hindering the rehabilitation process. The aim of our work was to determine if a single HA infiltration could minimize the effects of arthrogenic muscle inhibition in patients with KOA in the short term, using isokinetic dynamometry to evaluate the strength of the knee extensor and flexor muscles of the thigh. Thirty patients with KOA who underwent both clinical and isokinetic assessment, and that received a single injection of HA, were retrospectively included. Our results showed that a single intra-articular injection of HA significantly reduces pain and improves joint function at four weeks, while non-statistically significant improvements were observed for the reference isokinetic parameter (maximum torque) at both 90°/s and 180°/s. Further high-quality studies are necessary to confirm the results of our study.
Keywords: osteoarthritis; knee osteoarthritis; hyaluronic acid; injection; isokinetic dynamometer osteoarthritis; knee osteoarthritis; hyaluronic acid; injection; isokinetic dynamometer

Share and Cite

MDPI and ACS Style

Tarantino, D.; Forte, A.M.; Picone, A.; Sirico, F.; Ruosi, C. The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Retrospective Study. J. Pers. Med. 2024, 14, 784. https://doi.org/10.3390/jpm14080784

AMA Style

Tarantino D, Forte AM, Picone A, Sirico F, Ruosi C. The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Retrospective Study. Journal of Personalized Medicine. 2024; 14(8):784. https://doi.org/10.3390/jpm14080784

Chicago/Turabian Style

Tarantino, Domiziano, Alfonso Maria Forte, Antonio Picone, Felice Sirico, and Carlo Ruosi. 2024. "The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Retrospective Study" Journal of Personalized Medicine 14, no. 8: 784. https://doi.org/10.3390/jpm14080784

APA Style

Tarantino, D., Forte, A. M., Picone, A., Sirico, F., & Ruosi, C. (2024). The Effectiveness of a Single Hyaluronic Acid Injection in Improving Symptoms and Muscular Strength in Patients with Knee Osteoarthritis: A Multicenter, Retrospective Study. Journal of Personalized Medicine, 14(8), 784. https://doi.org/10.3390/jpm14080784

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop