Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Literature Search
2.2. Selection Criteria
2.3. Data Extraction
2.4. Quality Assessment
2.5. Statistical Analysis
3. Results
3.1. Quality Assessment
3.2. Main Characteristics of the Included Studies
3.3. The Diagnostic Performance of Anti-DFS70 Antibodies in the Exclusion of SARD
3.4. Heterogeneity
3.5. Publication Bias
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Authors | Country | ANA Detection Method | Titer | Anti-DFS70 Method | SARD Diagnosis | Non-SARD Prevalence | TP | FP | FN | TN |
---|---|---|---|---|---|---|---|---|---|---|
Fitch-Rogalsky et al., 2014 [2] | Canada | Hep-2000 (ImmunoConcepts) | 1:160 | CIA (Inova) | Classification criteria 1 | 74.0% | 31 | 2 | 123 | 52 |
Herold et al., 2013 [33] | Austria | Not specified | Not specified | CIA (Inova) | Medical record 1 | 87.6% | 68 | 3 | 193 | 34 |
Kang et al., 2019 [34] | South Korea | Kallestad HEp-2 Kit (Bio-Rad) | 1:40 | Western blot | Not specified 2 | 86.0% | 158 | 7 | 307 | 69 |
Kiefer et al., 2019 [35] | Germany | Not specified | 1:80 | CIA (Inova) | Clinical diagnosis 1 | 63.3% | 17 | 2 | 140 | 89 |
Lucas et al., 2018 [32] | New Zealand | HEp-2 I.I.F. (Inova) or EIA ANA Screening Test (Bio-Rad) | Not specified | CIA (Inova) | Not specified 2 | 51.7% | 7 | 1 | 102 | 101 |
Tan et al., 2020 [36] | Singapore | Hep 2010 (Euroimmun) | 1:80 | ELISA (Euroimmun) | Medical record 3 | 90.5% | 51 | 8 | 485 | 48 |
Tandaipan et al., 2020 [30] | Spain | Not specified | 1:80 | LIA (Euroimmun) | Not specified 2 | 80.4% | 35 | 3 | 47 | 17 |
Yumuk et al., 2020 [31] | Turkey | HEp 2010 (Euroimmun) | 1:100 | LIA (Euroimmun) | Medical record 4 | 85.1% | 334 | 34 | 1341 | 259 |
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Cheng, C.-F.; Shih, M.-C.; Lan, T.-Y.; Li, K.-J. Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis. Diagnostics 2021, 11, 1592. https://doi.org/10.3390/diagnostics11091592
Cheng C-F, Shih M-C, Lan T-Y, Li K-J. Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis. Diagnostics. 2021; 11(9):1592. https://doi.org/10.3390/diagnostics11091592
Chicago/Turabian StyleCheng, Chiao-Feng, Ming-Chieh Shih, Ting-Yuan Lan, and Ko-Jen Li. 2021. "Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis" Diagnostics 11, no. 9: 1592. https://doi.org/10.3390/diagnostics11091592