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Article

Cerebral Veins and Dural Sinuses Thrombosis: Data from a Monocentric Cohort Study of 55 Romanian Patients

by
Dragos Catalin Jianu
1,2,3,4,
Silviana Nina Jianu
5,
Razvan Bertici
1,2,3,*,
Nicoleta Iacob
6,
Sergiu Florin Arnautu
2,7,
Georgiana Munteanu
1,2,3,
Traian Flavius Dan
1,2,3,
Raphael Sadik
8,
Tudor Nicolae Jianu
1,
Any Axelerad
2,9,
Cristina Tudoran
2,10,
Andrei Gheorghe Marius Motoc
2,11,
Stefan Strilciuc
12,
Dafin Fior Muresanu
13 and
Ligia Petrica
2,4,14
1
First Division of Neurology, Department of Neurosciences, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no.2, 300041 Timisoara, Romania
2
Centre for Cognitive Research in Neuropsychiatric Pathology (NeuroPsy-Cog), Department of Neurosciences, Victor Babes University of Medicine and Pharmacy, 156 L. Rebreanu Ave., 300736 Timisoara, Romania
3
First Department of Neurology, Pius Brînzeu Clinical Emergency County Hospital, 156 L. Rebreanu Ave., 300736 Timisoara, Romania
4
Centre for Molecular Research in Nephrology and Vascular Pathology, Department of Internal Medicine II, Victor Babes University of Medicine and Pharmacy, 156 L. Rebreanu Ave., 300736 Timisoara, Romania
5
Department of Ophthalmology, Dr. Victor Popescu Military Emergency Hospital, 7 G. Lazar Ave, 300080 Timisoara, Romania
6
Department of Multidetector Computed Tomography and Magnetic Resonance Imaging, Neuromed Diagnostic Imaging Centre, 300218 Timisoara, Romania
7
Department of Internal Medicine I, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no.2, 300041 Timisoara, Romania
8
Department of Geriatrics-Rehabilitation, Riviera-Chablais Hospital, 3 Prairie Av, 1800 Vevey, Switzerland
9
Department of Neurology, General Medicine Faculty, Ovidius University, 900527 Constanta, Romania
10
Discipline of Cardiology, Department VII-Internal Medicine II, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no. 2, 300041 Timisoara, Romania
11
Department of Anatomy and Embryology, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no.2, 300041 Timisoara, Romania
12
Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, 32-38 Gheorghe Marinescu St., 400347 Cluj-Napoca, Romania
13
Department of Neurosciences, Iuliu Hațieganu University of Medicine and Pharmacy, No. 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
14
Division of Nephrology, Department of Internal Medicine II, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no.2, 300041 Timisoara, Romania
 
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Author to whom correspondence should be addressed.
Life 2026, 16(6), 875; https://doi.org/10.3390/life16060875 (registering DOI)
Submission received: 30 April 2026 / Revised: 17 May 2026 / Accepted: 21 May 2026 / Published: 23 May 2026
(This article belongs to the Special Issue An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT))
Versions Notes

Abstract

Cerebral venous sinus thrombosis (CVST) is a rare form of stroke with heterogeneous clinical presentation and etiological profile. This study aimed to evaluate the demographic, clinical, imaging, etiological, treatment, and outcome characteristics of CVST in a Romanian population. We conducted a retrospective monocentric cohort study including 55 patients diagnosed over a six-year period in a tertiary neurological center. CVST accounted for 1.2% of all stroke cases, with an incidence of 13.75 per million per year. Gender distribution was relatively balanced, differing from international cohorts, and traditional female-specific risk factors were less prominent. Thrombophilia (68.6%) and infections (38.2%) were the most frequent etiologies. Younger patients were more frequently associated with thrombophilia, while a higher inflammatory response was observed in older individuals; additionally, female patients showed a higher prevalence of the MTHFR C677T mutation. Transverse and sigmoid sinuses were the most affected, while cavernous sinus involvement was more frequent than typically reported and associated with infections. At discharge, long-term anticoagulation was recommended in 67.3% of patients, tailored to underlying etiology and risk profile. Outcomes were favorable, with 70–80% achieving a modified Rankin Scale score ≤2 at discharge and over 90% at 90-day follow-up, despite inconsistent correlation with imaging findings. These results highlight the heterogeneous nature of CVST and the need for comprehensive, individualized evaluation and management.
Keywords: cerebral venous sinus thrombosis; stroke; thrombophilia; neuroimaging; anticoagulation; clinical outcomes cerebral venous sinus thrombosis; stroke; thrombophilia; neuroimaging; anticoagulation; clinical outcomes

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MDPI and ACS Style

Jianu, D.C.; Jianu, S.N.; Bertici, R.; Iacob, N.; Arnautu, S.F.; Munteanu, G.; Dan, T.F.; Sadik, R.; Jianu, T.N.; Axelerad, A.; et al. Cerebral Veins and Dural Sinuses Thrombosis: Data from a Monocentric Cohort Study of 55 Romanian Patients. Life 2026, 16, 875. https://doi.org/10.3390/life16060875

AMA Style

Jianu DC, Jianu SN, Bertici R, Iacob N, Arnautu SF, Munteanu G, Dan TF, Sadik R, Jianu TN, Axelerad A, et al. Cerebral Veins and Dural Sinuses Thrombosis: Data from a Monocentric Cohort Study of 55 Romanian Patients. Life. 2026; 16(6):875. https://doi.org/10.3390/life16060875

Chicago/Turabian Style

Jianu, Dragos Catalin, Silviana Nina Jianu, Razvan Bertici, Nicoleta Iacob, Sergiu Florin Arnautu, Georgiana Munteanu, Traian Flavius Dan, Raphael Sadik, Tudor Nicolae Jianu, Any Axelerad, and et al. 2026. "Cerebral Veins and Dural Sinuses Thrombosis: Data from a Monocentric Cohort Study of 55 Romanian Patients" Life 16, no. 6: 875. https://doi.org/10.3390/life16060875

APA Style

Jianu, D. C., Jianu, S. N., Bertici, R., Iacob, N., Arnautu, S. F., Munteanu, G., Dan, T. F., Sadik, R., Jianu, T. N., Axelerad, A., Tudoran, C., Motoc, A. G. M., Strilciuc, S., Muresanu, D. F., & Petrica, L. (2026). Cerebral Veins and Dural Sinuses Thrombosis: Data from a Monocentric Cohort Study of 55 Romanian Patients. Life, 16(6), 875. https://doi.org/10.3390/life16060875

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