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Oligodendroglial Heterogeneity in Neuropsychiatric Disease

Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, 5, Little France Drive, Edinburgh EH16 4UU, UK
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Academic Editor: Nathalie Sol-Foulon
Life 2021, 11(2), 125; https://doi.org/10.3390/life11020125
Received: 14 January 2021 / Revised: 1 February 2021 / Accepted: 2 February 2021 / Published: 6 February 2021
(This article belongs to the Special Issue Myelin and Oligodendrocyte-Neuron Interactions)
Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and regional differences, as well as variation in cellular states, as evidenced by recent analysis at single-nuclei resolution. Increasingly, there is evidence to suggest that the highly heterogeneous nature of oligodendroglia might underpin their role in a range of CNS disorders, including those with neuropsychiatric symptoms. Understanding the role of oligodendroglial heterogeneity in this group of disorders might pave the way for novel approaches to identify biomarkers and develop treatments. View Full-Text
Keywords: oligodendrocyte; neuropsychiatric disease; heterogeneity; Huntington’s disease oligodendrocyte; neuropsychiatric disease; heterogeneity; Huntington’s disease
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MDPI and ACS Style

Bøstrand, S.M.K.; Williams, A. Oligodendroglial Heterogeneity in Neuropsychiatric Disease. Life 2021, 11, 125. https://doi.org/10.3390/life11020125

AMA Style

Bøstrand SMK, Williams A. Oligodendroglial Heterogeneity in Neuropsychiatric Disease. Life. 2021; 11(2):125. https://doi.org/10.3390/life11020125

Chicago/Turabian Style

Bøstrand, Sunniva M.K., and Anna Williams. 2021. "Oligodendroglial Heterogeneity in Neuropsychiatric Disease" Life 11, no. 2: 125. https://doi.org/10.3390/life11020125

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