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Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA

School of Life Sciences, Huxley Building, Keele University, Keele ST5 5BG, UK
Author to whom correspondence should be addressed.
Academic Editor: Bernhard Herrmann
Genes 2015, 6(3), 484-499;
Received: 29 May 2015 / Revised: 19 June 2015 / Accepted: 26 June 2015 / Published: 7 July 2015
(This article belongs to the Special Issue Long Noncoding RNAs)
PDF [432 KB, uploaded 7 July 2015]


It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and thereby offer novel opportunities for diagnosis and therapy. Of particular interest in this regard is GAS5 lncRNA, which is down-regulated in multiple cancers, with expression levels related to both clinico-pathological characteristics and patient prognosis. Functional studies have further shown that GAS5 lncRNA both inhibits the proliferation and promotes the apoptosis of multiple cell types, and that together these cellular mechanisms of action are likely to form the basis of its tumour suppressor action. At the same time, advances have been made in our understanding of the molecular mechanisms of GAS5 lncRNA action in recent years, including riborepression of certain steroid hormone receptors and sequestration of miR-21, impacting key regulatory pathways of cell survival. Overall this accumulating knowledge has the potential to improve both the diagnosis and treatment of cancer, and ultimately patient outcome. View Full-Text
Keywords: GAS5; lncRNA; cancer; tumour suppressor; apoptosis; cell proliferation GAS5; lncRNA; cancer; tumour suppressor; apoptosis; cell proliferation

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Pickard, M.R.; Williams, G.T. Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Genes 2015, 6, 484-499.

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