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Article

Genome-Wide Association Study of Arsenic Accumulation in Polished Rice

by
Zheng Dong
1,2,
Liang Guo
1,2,
Xiaoxiang Li
1,2,
Yongchao Li
1,2,
Wenqiang Liu
1,2,
Zuwu Chen
1,2,
Licheng Liu
1,2,
Zhixi Liu
1,2,
Yujing Guo
1,2 and
Xiaowu Pan
1,2,*
1
Hunan Rice Research Institute, Hunan Academy of Agricultural Sciences, Changsha 410125, China
2
Key Laboratory of Indica Rice Genetics and Breeding in the Middle and Lower Reaches of Yangtze River Valley, Ministry of Agriculture, Changsha 410125, China
*
Author to whom correspondence should be addressed.
Genes 2023, 14(12), 2186; https://doi.org/10.3390/genes14122186
Submission received: 24 October 2023 / Revised: 30 November 2023 / Accepted: 4 December 2023 / Published: 7 December 2023
(This article belongs to the Special Issue Genetics and Genomics of Rice)
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Abstract

The accumulation of arsenic (As) in rice poses a significant threat to food safety and human health. Breeding rice varieties with low As accumulation is an effective strategy for mitigating the health risks associated with arsenic-contaminated rice. However, the genetic mechanisms underlying As accumulation in rice grains remain incompletely understood. We evaluated the As accumulation capacity of 313 diverse rice accessions grown in As-contaminated soils with varying As concentrations. Six rice lines with low As accumulation were identified. Additionally, a genome-wide association studies (GWAS) analysis identified 5 QTLs significantly associated with As accumulation, with qAs4 being detected in both of the experimental years. Expression analysis demonstrated that the expression of LOC_Os04g50680, which encodes an MYB transcription factor, was up-regulated in the low-As-accumulation accessions compared to the high-As-accumulation accessions after As treatment. Therefore, LOC_Os04g50680 was selected as a candidate gene for qAs4. These findings provide insights for exploiting new functional genes associated with As accumulation and facilitating the development of low-As-accumulation rice varieties through marker-assisted breeding.
Keywords: arsenic; GWAS; MYB transcription factor; polished rice arsenic; GWAS; MYB transcription factor; polished rice

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MDPI and ACS Style

Dong, Z.; Guo, L.; Li, X.; Li, Y.; Liu, W.; Chen, Z.; Liu, L.; Liu, Z.; Guo, Y.; Pan, X. Genome-Wide Association Study of Arsenic Accumulation in Polished Rice. Genes 2023, 14, 2186. https://doi.org/10.3390/genes14122186

AMA Style

Dong Z, Guo L, Li X, Li Y, Liu W, Chen Z, Liu L, Liu Z, Guo Y, Pan X. Genome-Wide Association Study of Arsenic Accumulation in Polished Rice. Genes. 2023; 14(12):2186. https://doi.org/10.3390/genes14122186

Chicago/Turabian Style

Dong, Zheng, Liang Guo, Xiaoxiang Li, Yongchao Li, Wenqiang Liu, Zuwu Chen, Licheng Liu, Zhixi Liu, Yujing Guo, and Xiaowu Pan. 2023. "Genome-Wide Association Study of Arsenic Accumulation in Polished Rice" Genes 14, no. 12: 2186. https://doi.org/10.3390/genes14122186

APA Style

Dong, Z., Guo, L., Li, X., Li, Y., Liu, W., Chen, Z., Liu, L., Liu, Z., Guo, Y., & Pan, X. (2023). Genome-Wide Association Study of Arsenic Accumulation in Polished Rice. Genes, 14(12), 2186. https://doi.org/10.3390/genes14122186

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