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Volume 13
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10.3390/genes13010005
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Article

Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women

by
Mizuki Takaragawa
1,
Takuro Tobina
2,
Keisuke Shiose
3,
Ryo Kakigi
4,
Takamasa Tsuzuki
5,
Noriko Ichinoseki-Sekine
1,6,
Hiroshi Kumagai
1,
Hirofumi Zempo
7,
Eri Miyamoto-Mikami
1,
Hiroyuki Kobayashi
1,8,
Hisashi Naito
1 and
Noriyuki Fuku
1,*
1
Graduate School of Health and Sports Science, Juntendo University, Chiba 270-1695, Japan
2
Faculty of Nursing and Nutrition, University of Nagasaki, Nagasaki 851-2195, Japan
3
Faculty of Education, University of Miyazaki, Miyazaki 889-2192, Japan
4
Faculty of Management & Information Science, Josai International University, Chiba 283-8555, Japan
5
Faculty of Pharmacy, Meijo University, Aichi 468-8503, Japan
6
Faculty of Liberal Arts, The Open University of Japan, Chiba 261-8586, Japan
7
Faculty of Health and Nutrition, Tokyo Seiei College, Tokyo 124-8530, Japan
8
Mito Medical Center, Tsukuba University Hospital, Ibaraki 310-0015, Japan
*
Author to whom correspondence should be addressed.
Genes 2022, 13(1), 5; https://doi.org/10.3390/genes13010005
Submission received: 1 December 2021 / Revised: 16 December 2021 / Accepted: 17 December 2021 / Published: 21 December 2021
(This article belongs to the Special Issue Genetics and Sports Performance)
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Abstract

Human muscle fiber composition is heterogeneous and mainly determined by genetic factors. A previous study reported that experimentally induced iron deficiency in rats increases the proportion of fast-twitch muscle fibers. Iron status has been reported to be affected by genetic factors. As the TMPRSS6 rs855791 T/C and HFE rs1799945 C/G polymorphisms are strongly associated with iron status in humans, we hypothesized that the genotype score (GS) based on these polymorphisms could be associated with the muscle fiber composition in humans. Herein, we examined 214 Japanese individuals, comprising of 107 men and 107 women, for possible associations of the GS for iron status with the proportion of myosin heavy chain (MHC) isoforms (I, IIa, and IIx) as markers of muscle fiber composition. No statistically significant correlations were found between the GS for iron status and the proportion of MHC isoforms in all participants. When the participants were stratified based on sex, women showed positive and negative correlations of the GS with MHC-IIa (age-adjusted p = 0.020) and MHC-IIx (age-adjusted p = 0.011), respectively. In contrast, no correlation was found in men. In women, a 1-point increase in the GS was associated with 2.42% higher MHC-IIa level and 2.72% lower MHC-IIx level. Our results suggest that the GS based on the TMPRSS6 rs855791 T/C and HFE rs1799945 C/G polymorphisms for iron status is associated with muscle fiber composition in women.
Keywords: genetic polymorphism; transmembrane serine protease 6; TMPRSS6; matriptase 2; homeostatic iron regulator protein; HFE; anemia; iron deficiency; myosin heavy chain; skeletal muscle genetic polymorphism; transmembrane serine protease 6; TMPRSS6; matriptase 2; homeostatic iron regulator protein; HFE; anemia; iron deficiency; myosin heavy chain; skeletal muscle

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MDPI and ACS Style

Takaragawa, M.; Tobina, T.; Shiose, K.; Kakigi, R.; Tsuzuki, T.; Ichinoseki-Sekine, N.; Kumagai, H.; Zempo, H.; Miyamoto-Mikami, E.; Kobayashi, H.; et al. Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women. Genes 2022, 13, 5. https://doi.org/10.3390/genes13010005

AMA Style

Takaragawa M, Tobina T, Shiose K, Kakigi R, Tsuzuki T, Ichinoseki-Sekine N, Kumagai H, Zempo H, Miyamoto-Mikami E, Kobayashi H, et al. Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women. Genes. 2022; 13(1):5. https://doi.org/10.3390/genes13010005

Chicago/Turabian Style

Takaragawa, Mizuki, Takuro Tobina, Keisuke Shiose, Ryo Kakigi, Takamasa Tsuzuki, Noriko Ichinoseki-Sekine, Hiroshi Kumagai, Hirofumi Zempo, Eri Miyamoto-Mikami, Hiroyuki Kobayashi, and et al. 2022. "Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women" Genes 13, no. 1: 5. https://doi.org/10.3390/genes13010005

APA Style

Takaragawa, M., Tobina, T., Shiose, K., Kakigi, R., Tsuzuki, T., Ichinoseki-Sekine, N., Kumagai, H., Zempo, H., Miyamoto-Mikami, E., Kobayashi, H., Naito, H., & Fuku, N. (2022). Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women. Genes, 13(1), 5. https://doi.org/10.3390/genes13010005

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