Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice
1
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands
2
Sylics (Synaptologics BV), 1008 BA Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Cells 2020, 9(9), 2119; https://doi.org/10.3390/cells9092119
Received: 28 August 2020
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Revised: 15 September 2020
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Accepted: 17 September 2020
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Published: 18 September 2020
(This article belongs to the Special Issue Neuron-Glia Interactions)
Myelination greatly increases the speed of action potential propagation of neurons, thereby enhancing the efficacy of inter-neuronal communication and hence, potentially, optimizing the brain’s signal processing capability. The impact of genetic variation on the extent of axonal myelination and its consequences for brain functioning remain to be determined. Here we investigated this question using a genetic reference panel (GRP) of mouse BXD recombinant inbred (RI) strains, which partly model genetic diversity as observed in human populations, and which show substantial genetic differences in a variety of behaviors, including learning, memory and anxiety. We found coherent differences in the expression of myelin genes in brain tissue of RI strains of the BXD panel, with the largest differences in the hippocampus. The parental C57BL/6J (C57) and DBA/2J (DBA) strains were on opposite ends of the expression spectrum, with C57 showing higher myelin transcript expression compared with DBA. Our experiments showed accompanying differences between C57 and DBA in myelin protein composition, total myelin content, and white matter conduction velocity. Finally, the hippocampal myelin gene expression of the BXD strains correlated significantly with behavioral traits involving anxiety and/or activity. Taken together, our data indicate that genetic variation in myelin gene expression translates to differences observed in myelination, axonal conduction speed, and possibly in anxiety/activity related behaviors.
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Keywords:
genetics; oligodendrocyte; gene expression; myelin; behavior
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MDPI and ACS Style
Goudriaan, A.; Loos, M.; Spijker, S.; Smit, A.B.; Verheijen, M.H.G. Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice. Cells 2020, 9, 2119. https://doi.org/10.3390/cells9092119
AMA Style
Goudriaan A, Loos M, Spijker S, Smit AB, Verheijen MHG. Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice. Cells. 2020; 9(9):2119. https://doi.org/10.3390/cells9092119
Chicago/Turabian StyleGoudriaan, Andrea, Maarten Loos, Sabine Spijker, August B. Smit, and Mark H.G. Verheijen. 2020. "Genetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice" Cells 9, no. 9: 2119. https://doi.org/10.3390/cells9092119
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