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Volume 13
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10.3390/cells13090770
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Review

From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment?

by
Cristiana Vilela
1,
Bruna Araújo
2,3,4,
Carla Soares-Guedes
1,4,
Rita Caridade-Silva
4,
Joana Martins-Macedo
2,3,4,
Catarina Teixeira
4,
Eduardo D. Gomes
1,
Cristina Prudêncio
1,
Mónica Vieira
1 and
Fábio G. Teixeira
2,3,4,*
1
Center for Translational Health and Medical Biotechnology Research (TBIO)/Health Research Network (RISE-Health), ESS, Polytechnic of Porto, R. Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal
2
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
3
ICVS/3B’s Associate Lab, PT Government Associated Lab, 4710-057/4805-017 Braga/Guimarães, Portugal
4
i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal
*
Author to whom correspondence should be addressed.
Cells 2024, 13(9), 770; https://doi.org/10.3390/cells13090770
Submission received: 2 April 2024 / Revised: 24 April 2024 / Accepted: 26 April 2024 / Published: 30 April 2024
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Abstract

Parkinson’s disease (PD) is recognized as the second most prevalent primary chronic neurodegenerative disorder of the central nervous system. Clinically, PD is characterized as a movement disorder, exhibiting an incidence and mortality rate that is increasing faster than any other neurological condition. In recent years, there has been a growing interest concerning the role of the gut microbiota in the etiology and pathophysiology of PD. The establishment of a brain–gut microbiota axis is now real, with evidence denoting a bidirectional communication between the brain and the gut microbiota through metabolic, immune, neuronal, and endocrine mechanisms and pathways. Among these, the vagus nerve represents the most direct form of communication between the brain and the gut. Given the potential interactions between bacteria and drugs, it has been observed that the therapies for PD can have an impact on the composition of the microbiota. Therefore, in the scope of the present review, we will discuss the current understanding of gut microbiota on PD and whether this may be a new paradigm for treating this devastating disease.
Keywords: Parkinson’s disease; microbiome; gut–brain axis Parkinson’s disease; microbiome; gut–brain axis

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MDPI and ACS Style

Vilela, C.; Araújo, B.; Soares-Guedes, C.; Caridade-Silva, R.; Martins-Macedo, J.; Teixeira, C.; Gomes, E.D.; Prudêncio, C.; Vieira, M.; Teixeira, F.G. From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? Cells 2024, 13, 770. https://doi.org/10.3390/cells13090770

AMA Style

Vilela C, Araújo B, Soares-Guedes C, Caridade-Silva R, Martins-Macedo J, Teixeira C, Gomes ED, Prudêncio C, Vieira M, Teixeira FG. From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? Cells. 2024; 13(9):770. https://doi.org/10.3390/cells13090770

Chicago/Turabian Style

Vilela, Cristiana, Bruna Araújo, Carla Soares-Guedes, Rita Caridade-Silva, Joana Martins-Macedo, Catarina Teixeira, Eduardo D. Gomes, Cristina Prudêncio, Mónica Vieira, and Fábio G. Teixeira. 2024. "From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment?" Cells 13, no. 9: 770. https://doi.org/10.3390/cells13090770

APA Style

Vilela, C., Araújo, B., Soares-Guedes, C., Caridade-Silva, R., Martins-Macedo, J., Teixeira, C., Gomes, E. D., Prudêncio, C., Vieira, M., & Teixeira, F. G. (2024). From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment? Cells, 13(9), 770. https://doi.org/10.3390/cells13090770

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