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Review
Peer-Review Record

Iron-Induced Oxidative Stress in Human Diseases

Cells 2022, 11(14), 2152; https://doi.org/10.3390/cells11142152
by Teruyuki Kawabata
Reviewer 1:
Reviewer 2:
Cells 2022, 11(14), 2152; https://doi.org/10.3390/cells11142152
Submission received: 20 May 2022 / Revised: 30 June 2022 / Accepted: 4 July 2022 / Published: 8 July 2022
(This article belongs to the Special Issue Molecular Mechanism of Stress, Stress Response, and Adaptation)

Round 1

Reviewer 1 Report

Comments:

  The author aimed to clarify the relation of iron in extracellular and intracellular spaces with generation of ROS. Detailed descriptions and rich charts are used to support the author's views and theories. The overall logic of this article is clear. However, there are still some problems that need to be modified.

Q1: The title of this manuscript was Iron-induced oxidative stress: the mastermind behind human diseases., but the main point in your context was to introduce iron and its transition biophysical and chemical aspect. It seems to be abstract and unintelligible. I think the role and mechanism of iron - induced oxidative stress in disease should be added.

Q2: A detail: the citation format of reference should be checked and modified. For example, the citation in line 293 is not shown.

Q3: The relationship between iron and ROS generation in this manuscript should be more specific.

Author Response

Please see the attachment.

 

Author Response File: Author Response.pdf

Reviewer 2 Report

see attached file

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

see attached

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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