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Polymers 2017, 9(7), 276; https://doi.org/10.3390/polym9070276

Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH

1
CNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, France
2
Université Paul Sabatier, Université de Toulouse, 118 Route de Narbonne, Toulouse 31062, France
*
Author to whom correspondence should be addressed.
Academic Editor: Shin-ichi Yusa
Received: 20 June 2017 / Revised: 3 July 2017 / Accepted: 6 July 2017 / Published: 11 July 2017
(This article belongs to the Special Issue Polypeptide Containing Polymers)
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Abstract

Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes. View Full-Text
Keywords: smart polypeptides; imidazole-containing polymers; helix-to-coil transition; poly(lysine); pH-responsive smart polypeptides; imidazole-containing polymers; helix-to-coil transition; poly(lysine); pH-responsive
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Piedra-Arroni, E.; Makni, F.; Severac, L.; Stigliani, J.-L.; Pratviel, G.; Bonduelle, C. Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH. Polymers 2017, 9, 276.

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