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Polymers
Volume 14
Issue 5
10.3390/polym14050936
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Review

pH-Responsive Nanocarriers in Cancer Therapy

by
Nour M. AlSawaftah
1,2,
Nahid S. Awad
1,
William G. Pitt
3 and
Ghaleb A. Husseini
1,2,*
1
Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab Emirates
2
Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab Emirates
3
Chemical Engineering Department, Brigham Young University, Provo, UT 84602, USA
*
Author to whom correspondence should be addressed.
Polymers 2022, 14(5), 936; https://doi.org/10.3390/polym14050936
Submission received: 28 January 2022 / Revised: 17 February 2022 / Accepted: 21 February 2022 / Published: 26 February 2022
(This article belongs to the Special Issue Polymers for Biomedical Imaging and Therapy)
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Abstract

A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy.
Keywords: nanoparticles; pH; drug delivery; cancer nanoparticles; pH; drug delivery; cancer

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MDPI and ACS Style

AlSawaftah, N.M.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. pH-Responsive Nanocarriers in Cancer Therapy. Polymers 2022, 14, 936. https://doi.org/10.3390/polym14050936

AMA Style

AlSawaftah NM, Awad NS, Pitt WG, Husseini GA. pH-Responsive Nanocarriers in Cancer Therapy. Polymers. 2022; 14(5):936. https://doi.org/10.3390/polym14050936

Chicago/Turabian Style

AlSawaftah, Nour M., Nahid S. Awad, William G. Pitt, and Ghaleb A. Husseini. 2022. "pH-Responsive Nanocarriers in Cancer Therapy" Polymers 14, no. 5: 936. https://doi.org/10.3390/polym14050936

APA Style

AlSawaftah, N. M., Awad, N. S., Pitt, W. G., & Husseini, G. A. (2022). pH-Responsive Nanocarriers in Cancer Therapy. Polymers, 14(5), 936. https://doi.org/10.3390/polym14050936

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