Table of Contents
Crystals, Volume 10, Issue 4 (April 2020) – 102 articles
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Cover Story (view full-size image) Curcumin and its derivatives demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC) are natural [...] Read more. Curcumin and its derivatives demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC) are natural ingredients of the plant rhizome of Curcuma longa L. Together they are known as curcuminoids. Despite their strong similarity in molecular structure, their pharmacological activity and therapeutic effects can differ, which requires isolation of curcumin in pure state. In the article, crystallization-based separation of curcumin from extract-similar curcuminoid mixtures is studied. Based on solubility and supersolubility data of pure curcumin and curcumin in the initial mixture, seeded cooling crystallization procedures were derived using different solvents/solvent systems. As a result, crystalline curcumin of up to 99.4% purity, free of BDMC and depleted DMC content, was provided in a simple single crystallization step. Opportunities to further enhance total curcumin recovery by optimizing the crystallization strategy are highlighted. View