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Catalysts, Volume 8, Issue 2 (February 2018)
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Cover Story (view full-size image) (S)-Rivastigmine is a blockbuster drug heavily used for the treatment of mild to moderate dementia [...] Read more. (S)-Rivastigmine is a blockbuster drug heavily used for the treatment of mild to moderate dementia of the Alzheimer’s type. An original whole-cell-based and environmentally friendly chemoenzymatic approach has been developed for the obtainment of the target eutomer in four steps, in overall 78% yield and 98% ee. The key step is the stereoselective bioreduction in a phosphate buffered saline medium of an aromatic ketone catalyzed by cheap and easily available Lactobacillus reuteri DSM 20016 whole cells. Interestingly, the described protocol has also been successfully performed on a gram scale, and is amenable for being scaled-up to industrial level. View this paper