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Catalysts 2018, 8(2), 75; https://doi.org/10.3390/catal8020075

One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules

1
EntreChem SL, Vivero Ciencias de la Salud, Santo Domingo de Guzmán, 33011 Oviedo, Spain
2
Laboratorio de Compuestos Organometálicos y Catálisis (Unidad Asociada al CSIC), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, E-33006 Oviedo, Spain
*
Authors to whom correspondence should be addressed.
Received: 22 January 2018 / Revised: 7 February 2018 / Accepted: 8 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Chiral Building Blocks via Asymmetric Catalysis)
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Abstract

During the last decade, the combination of different metal- and bio-catalyzed organic reactions in aqueous media has permitted the flourishing of a variety of one-pot asymmetric multi-catalytic reactions devoted to the construction of enantiopure and high added-value chemicals under mild reaction conditions (usually room temperature) and in the presence of air. Herein, a comprehensive account of the state-of-the-art in the development of catalytic networks by combining metallic and biological catalysts in aqueous media (the natural environment of enzymes) is presented. Among others, the combination of metal-catalyzed isomerizations, cycloadditions, hydrations, olefin metathesis, oxidations, C-C cross-coupling and hydrogenation reactions, with several biocatalyzed transformations of organic groups (enzymatic reduction, epoxidation, halogenation or ester hydrolysis), are discussed. View Full-Text
Keywords: one-pot processes; cascade reactions; tandem catalysis; metal-catalysis; biocatalysis; enantioselective; water one-pot processes; cascade reactions; tandem catalysis; metal-catalysis; biocatalysis; enantioselective; water
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Ríos-Lombardía, N.; García-Álvarez, J.; González-Sabín, J. One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules. Catalysts 2018, 8, 75.

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