One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules
1
EntreChem SL, Vivero Ciencias de la Salud, Santo Domingo de Guzmán, 33011 Oviedo, Spain
2
Laboratorio de Compuestos Organometálicos y Catálisis (Unidad Asociada al CSIC), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, E-33006 Oviedo, Spain
*
Authors to whom correspondence should be addressed.
Catalysts 2018, 8(2), 75; https://doi.org/10.3390/catal8020075
Received: 22 January 2018
/
Revised: 7 February 2018
/
Accepted: 8 February 2018
/
Published: 10 February 2018
During the last decade, the combination of different metal- and bio-catalyzed organic reactions in aqueous media has permitted the flourishing of a variety of one-pot asymmetric multi-catalytic reactions devoted to the construction of enantiopure and high added-value chemicals under mild reaction conditions (usually room temperature) and in the presence of air. Herein, a comprehensive account of the state-of-the-art in the development of catalytic networks by combining metallic and biological catalysts in aqueous media (the natural environment of enzymes) is presented. Among others, the combination of metal-catalyzed isomerizations, cycloadditions, hydrations, olefin metathesis, oxidations, C-C cross-coupling and hydrogenation reactions, with several biocatalyzed transformations of organic groups (enzymatic reduction, epoxidation, halogenation or ester hydrolysis), are discussed.
View Full-Text
Keywords:
one-pot processes; cascade reactions; tandem catalysis; metal-catalysis; biocatalysis; enantioselective; water
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Ríos-Lombardía, N.; García-Álvarez, J.; González-Sabín, J. One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules. Catalysts 2018, 8, 75. https://doi.org/10.3390/catal8020075
AMA Style
Ríos-Lombardía N, García-Álvarez J, González-Sabín J. One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules. Catalysts. 2018; 8(2):75. https://doi.org/10.3390/catal8020075
Chicago/Turabian StyleRíos-Lombardía, Nicolás, Joaquín García-Álvarez, and Javier González-Sabín. 2018. "One-Pot Combination of Metal- and Bio-Catalysis in Water for the Synthesis of Chiral Molecules" Catalysts 8, no. 2: 75. https://doi.org/10.3390/catal8020075
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
