Table of Contents
Cancers, Volume 9, Issue 11 (November 2017)
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Cover Story (view full-size image) Whilst the near instantaneous physical interaction of radiation energy with living cells leaves [...] Read more. Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, how damage is recognized, repaired or resolved varies across the population. Radiosensitivity is a multi-dimensional problem that spans levels of tissue organization, time, people, patients and physics. Radiosensitive individuals may be at increased risk of radiotherapy-induced second cancers. Functional assays for cellular radiosensitivity represent a strategy to identify radiosensitive patients before radiotherapy begins, without needing to discover or evaluate the impact of the precise genetic determinants. View the paper