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Genomic Destabilization Triggered by Replication Stress during Senescence

Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan
Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0373, Japan
Department of Applied Chemistry, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
Author to whom correspondence should be addressed.
Cancers 2017, 9(11), 159;
Received: 25 September 2017 / Revised: 13 November 2017 / Accepted: 20 November 2017 / Published: 21 November 2017
(This article belongs to the Collection Histone Modification in Cancer)
PDF [1021 KB, uploaded 21 November 2017]


Most cancers develop after middle age, and are often associated with multiple mutations and genomic instability, implying that genomic destabilization is critical for age-related tumor development. In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which is associated with a higher risk of genomic destabilization; and (2) the contributions of genomic destabilization to cancer development. View Full-Text
Keywords: genomic instability; senescence; DNA replication stress; cancer development genomic instability; senescence; DNA replication stress; cancer development

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Minakawa, Y.; Shimizu, A.; Matsuno, Y.; Yoshioka, K.-I. Genomic Destabilization Triggered by Replication Stress during Senescence. Cancers 2017, 9, 159.

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