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Stat3 and Gap Junctions in Normal and Lung Cancer Cells

by Stephanie Guy 1,†, Mulu Geletu 2,†,‡, Rozanne Arulanandam 1,§ and Leda Raptis 1,2,*
1
Department of Pathology, Queen's University, Kingston, ON K7L 3N6, Canada
2
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Present address: Department of Chemical and Physical Sciences, University of Toronto, Mississauga, William Davis 3126B Room 3023, 3359 Mississauga Rd. N, Mississauga, ON L5L 1C6, Canada
§
Present address: Department of Pathology and Molecular Medicine, Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada;
Cancers 2014, 6(2), 646-662; https://doi.org/10.3390/cancers6020646
Received: 14 November 2013 / Revised: 11 February 2014 / Accepted: 27 February 2014 / Published: 25 March 2014
(This article belongs to the Special Issue STAT3 Signalling in Cancer: Friend or Foe)
Gap junctions are channels linking the interiors of neighboring cells. A reduction in gap junctional intercellular communication (GJIC) correlates with high cell proliferation, while oncogene products such as Src suppress GJIC, through the Ras/Raf/Erk and other effector pathways. High Src activity was found to correlate with high levels of the Src effector, Signal Transducer and Activator of Transcription-3 (Stat3) in its tyrosine-705 phosphorylated, i.e., transcriptionally activated form, in the majority of Non-Small Cell Lung Cancer lines examined. However, Stat3 inhibition did not restore GJIC in lines with high Src activity. In the contrary, Stat3 inhibition in normal cells or in lines with low Src activity and high GJIC eliminated gap junctional communication. Therefore, despite the fact that Stat3 is growth promoting and in an activated form acts like an oncogene, it is actually required for junctional permeability. View Full-Text
Keywords: signal transducer and activator of transcription-3; gap junctions; connexin43 signal transducer and activator of transcription-3; gap junctions; connexin43
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Guy, S.; Geletu, M.; Arulanandam, R.; Raptis, L. Stat3 and Gap Junctions in Normal and Lung Cancer Cells. Cancers 2014, 6, 646-662.

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