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Current Therapeutic Strategies and Novel Approaches in Osteosarcoma

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INSERM, UMR 957, 1 Rue Gaston Veil, 44035 Nantes, France
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Physiopathologie de la Résorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Université de Nantes, Nantes Atlantique Universités, 1 Rue Gaston Veil, 44035 Nantes, France
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Equipe Labellisee Ligue 2012, Nantes, 44035 France
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Nantes University Hospital, Nantes 44035, France
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Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan
*
Author to whom correspondence should be addressed.
Cancers 2013, 5(2), 591-616; https://doi.org/10.3390/cancers5020591
Received: 22 March 2013 / Revised: 28 April 2013 / Accepted: 9 May 2013 / Published: 24 May 2013
Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of multi-agent chemotherapy, surgery and radiation, which is not fully adequate for osteosarcoma treatment. Innovative drugs and approaches are needed to further improve outcome in osteosarcoma patients. This review describes the current management of osteosarcoma as well as potential new therapies. View Full-Text
Keywords: osteosarcoma; chemotherapy; surgery; radiotherapy; multidisciplinary treatment; emerging drugs osteosarcoma; chemotherapy; surgery; radiotherapy; multidisciplinary treatment; emerging drugs
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Ando, K.; Heymann, M.-F.; Stresing, V.; Mori, K.; Rédini, F.; Heymann, D. Current Therapeutic Strategies and Novel Approaches in Osteosarcoma. Cancers 2013, 5, 591-616.

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