- Editorial
2,255 Views
4 Pages
Gastrointestinal cancer is one of the most common malignancies worldwide [...]
- 4.4Impact Factor
- 8.8CiteScore
- 21 daysTime to First Decision
Cancers, Volume 16, Issue 8
April-2 2024 - 168 articles
Cover Story: Hepatocellular Carcinoma (HCC) is the third leading cause of cancer-related death and the sixth-most-diagnosed malignancy. Alpha-fetoprotein (AFP) is a traditional, ubiquitous biomarker. However, there increasing interest in using multiple biomarkers to optimize care. AFP, AFP-L3, and Prothrombin with vitamin K absence II (DCP) are useful, but have also established and significant limitations. ctDNA, genomic glycosylation, and even totally non-invasive salivary metabolomics/miRNA demonstrate great promise for both screening and surveillance, but lack large-scale prospective validation. We provide an update on the clinically available and emerging biomarkers for HCC, focusing on their respective clinical strengths and weaknesses. View this paper
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Articles (168)
- Article
15 Citations
3,111 Views
11 Pages
Robot-Assisted Radical Prostatectomy Performed with the Novel Surgical Robotic Platform Hugo™ RAS: Monocentric First Series of 132 Cases Reporting Surgical, and Early Functional and Oncological Outcomes at a Tertiary Referral Robotic Center
- Angelo Totaro,
- Eros Scarciglia,
- Filippo Marino,
- Marco Campetella,
- Carlo Gandi,
- Mauro Ragonese,
- Riccardo Bientinesi,
- Giuseppe Palermo,
- Francesco Pio Bizzarri and
- Antonio Cretì
- + 7 authors
Background: Robotic-assisted surgery is the gold standard for performing radical prostatectomy (RARP), with new robotic devices such as HugoTM RAS gaining prominence worldwide. Objective: We report the surgical, perioperative, and early postoperative...
- Editorial
2 Citations
1,591 Views
5 Pages
Treatment of Gastric Cancer Means Surgery, but Not Surgery Alone
- Manrica Fabbi,
- Christina D. Bali,
- Georgios D. Lianos and
- Stefano Rausei
Despite numerous studies, gastric cancer (GC) still presents a high mortality rate in Eastern and Western countries, increasing attention for new therapeutic strategies [...]
- Review
16 Citations
7,619 Views
22 Pages
Signaling by Type I Interferons in Immune Cells: Disease Consequences
- Markella Zannikou,
- Eleanor N. Fish and
- Leonidas C. Platanias
This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-...
- Review
21 Citations
8,506 Views
29 Pages
Chimeric Antigen Receptor (CAR) T-Cell Therapy in Hematologic Malignancies: Clinical Implications and Limitations
- Philipp Blüm and
- Sabine Kayser
Chimeric antigen receptor (CAR) T-cell therapy has become a powerful treatment option in B-cell and plasma cell malignancies, and many patients have benefited from its use. To date, six CAR T-cell products have been approved by the FDA and EMA, and m...
- Article
1 Citations
1,996 Views
11 Pages
No Racial Disparities Observed Using Point-of-Care Genetic Counseling and Testing for Endometrial and Ovarian Cancer in a Diverse Patient Population: A Retrospective Cohort Study
- Michael Kim,
- Judy Hayek,
- Cheyenne Acker,
- Anjile An,
- Peilin Zhang,
- Constantine Gorelick and
- Margaux J. Kanis
We investigated genetic counseling and testing rates for patients with gynecologic malignancy at a tertiary care center with a large minority population. Our retrospective cohort included newly diagnosed epithelial ovarian, fallopian tube, peritoneal...
- Systematic Review
9 Citations
3,351 Views
11 Pages
Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis
- Kamil Safiejko,
- Michal Pedziwiatr,
- Michal Pruc,
- Radoslaw Tarkowski,
- Marcin Juchimiuk,
- Marian Domurat,
- Jacek Smereka,
- Khikmat Anvarov,
- Przemyslaw Sielicki and
- Krzysztof Kurek
- + 1 author
Colorectal cancer is the third most common cancer worldwide, and the liver is the most common localization of metastatic disease. The incidence of minimally invasive liver surgery is increasing, and robotic surgery (RLR) is believed to overcome some...
- Article
2,020 Views
12 Pages
Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma
- Dino Podlesek,
- Friederike Beyer,
- Majd Alkhatib,
- Dirk Daubner,
- Mido Max Hijazi,
- Jerry Hadi Juratli,
- Susanne Weise,
- Ilker Y. Eyüpoglu,
- Gabriele Schackert and
- Tareq A. Juratli
- + 1 author
Purpose: The study aims to examine the possible correlation between genomic alterations and preoperative olfactory function in patients with olfactory groove meningioma (OGM), due to the frequent presence of olfactory impairment. Methods: We utilised...
- Review
11 Citations
3,863 Views
17 Pages
Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era
- Ari D. Kappel,
- Rohan Jha,
- Saibaba Guggilapu,
- William J. Smith,
- Abdullah H. Feroze,
- Adam A. Dmytriw,
- Juan Vicenty-Padilla,
- Rodolfo E. Alcedo Guardia,
- Florian A. Gessler and
- Nirav J. Patel
- + 5 authors
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selec...
- Article
1 Citations
3,929 Views
23 Pages
Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma
- Richard T. Waldron,
- Aurelia Lugea,
- Hui-Hua Chang,
- Hsin-Yuan Su,
- Crystal Quiros,
- Michael S. Lewis,
- Mingtian Che,
- V. Krishnan Ramanujan,
- Enrique Rozengurt and
- Guido Eibl
- + 1 author
Diet-induced obesity (DIO) promotes pancreatic ductal adenocarcinoma (PDAC) in mice expressing KRasG12D in the pancreas (KC mice), but the precise mechanisms remain unclear. Here, we performed multiplex quantitative proteomic and phosphoproteomic ana...
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Cancers - ISSN 2072-6694