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Review
Peer-Review Record

Evolving Clinical Utility of Liquid Biopsy in Gastrointestinal Cancers

Cancers 2019, 11(8), 1164; https://doi.org/10.3390/cancers11081164
by Richard A. Jacobson 1, Emily Munding 1, Dana M. Hayden 1, Mia Levy 2,3, Timothy M. Kuzel 2,3, Sam G. Pappas 1 and Ashiq Masood 2,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Cancers 2019, 11(8), 1164; https://doi.org/10.3390/cancers11081164
Submission received: 25 July 2019 / Revised: 30 July 2019 / Accepted: 6 August 2019 / Published: 13 August 2019
(This article belongs to the Special Issue Liquid Biopsy for Cancer)

Round 1

Reviewer 1 Report

The authors have addressed my comments. Minor suggestions-

 

·        Lines 90-92: “CTCs are identified via nucleic acid amplification of mRNA for epithelial cellular adhesion molecule (EpCAM), carcinoembryonic antigen (CEA) or cytokeratin (16), or further immunolabeling of specific surface antigens”  -- consider reworking this sentence for accuracy

·        Line 309 typo: “on study”

·        Line 318 typo: “that CTCs”

 

Author Response

We appreciate reviewer's comments:

·        Lines 90-92: “CTCs are identified via nucleic acid amplification of mRNA for epithelial cellular adhesion molecule (EpCAM), carcinoembryonic antigen (CEA) or cytokeratin (16), or further immunolabeling of specific surface antigens”  -- consider reworking this sentence for accuracy

·        Line 309 typo: “on study”

·        Line 318 typo: “that CTCs”

 

All advised  edits have been made in this version of the manuscript.

 

Reviewer 2 Report

Well revised, acceptable for publication

Author Response

Thanks for the positive response. We appreciate taking time to review our manuscript.

Reviewer 3 Report

All previous concerns have been addressed.

Author Response

Thanks for the positive response. We appreciate taking time to review our manuscript.

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