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Micromachines, Volume 15, Issue 1
January 2024 - 166 articles
Cover Story: For drug development, microfluidic devices are important for long-term experiments using organoids and tissues. While the devices extend culture duration, microbubbles often form inside and damage and starve the cells on the organoids and tissues. A microbubble removal method using negative pressure from the devices composed of polydimethylsiloxane (PDMS) has been reported. However, negative pressure is applied to entire devices, and this affects the cells in the device. In this study, a local microbubble removal method was developed using a device with thin PDMS sidewalls. The thin sidewalls counterbalanced the negative and atmospheric pressures, thereby localizing the negative pressure near the negatively pressurized chamber. Microbubbles were removed only near the chamber, whereas those away from the chamber were not removed. View this paper
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Micromachines - ISSN 2072-666XCreative Common CC BY license