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Toxins, Volume 8, Issue 5

May 2016 - 38 articles

Cover Story: Micrurus clarki is a rare coral snake, distributed from the Southeastern Pacific region of Costa Rica (orange shade in the figure) to Western Colombia. Researchers from the University of Costa Rica and the University of Antioquia, studied its venom for the first time. By applying proteomic tools through an analytical strategy known as 'venomics', a detailed portrait of the venom protein composition was obtained. This was complemented with a characterization of toxic activities and antibody neutralization studies, together with the isolation of a novel 'three-finger toxin', clarkitoxin-I, the first protein to be sequenced from the venom of this snake species.View this article.
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Articles (38)

  • Article
  • Open Access
43 Citations
8,041 Views
16 Pages

Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor

  • Daning Shi,
  • Xiaojuan Hou,
  • Lei Wang,
  • Yitian Gao,
  • Di Wu,
  • Xinping Xi,
  • Mei Zhou,
  • Hang Fai Kwok,
  • Jinao Duan and
  • Tianbao Chen
  • + 1 author

12 May 2016

The dermaseptin antimicrobial peptide family contains members of 27–34 amino acids in length that have been predominantly isolated from the skins/skin secretions of phyllomedusine leaf frogs. By use of a degenerate primer in Rapid amplification of cD...

  • Meeting Report
  • Open Access
11 Citations
7,768 Views
37 Pages

12 May 2016

The association research platform MYTOX “Mycotoxins and Toxigenic Moulds” held the 5th meeting of its International Symposium in Ghent, Belgium on 11 May 2016.[...]

  • Article
  • Open Access
36 Citations
9,155 Views
15 Pages

Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells

  • Eleonora Turrini,
  • Cinzia Calcabrini,
  • Piero Sestili,
  • Elena Catanzaro,
  • Elena De Gianni,
  • Anna Rita Diaz,
  • Patrizia Hrelia,
  • Massimo Tacchini,
  • Alessandra Guerrini and
  • Barbara Canonico
  • + 3 authors

12 May 2016

Cancer chemotherapy is characterized by an elevated intrinsic toxicity and the development of drug resistance. Thus, there is a compelling need for new intervention strategies with an improved therapeutic profile. Immunogenic cell death (ICD) represe...

  • Article
  • Open Access
20 Citations
5,979 Views
10 Pages

Monoclonal IgA Antibodies for Aflatoxin Immunoassays

  • Özlem Ertekin,
  • Şerife Şeyda Pirinçci and
  • Selma Öztürk

12 May 2016

Antibody based techniques are widely used for the detection of aflatoxins which are potent toxins with a high rate of occurrence in many crops. We developed a murine monoclonal antibody of immunoglobulin A (IgA) isotype with a strong binding affinity...

  • Article
  • Open Access
15 Citations
7,329 Views
19 Pages

The Draft Genome Sequence of the Yersinia entomophaga Entomopathogenic Type Strain MH96T

  • Mark R. H. Hurst,
  • Amy Beattie,
  • Eric Altermann,
  • Roger M. Moraga,
  • Lincoln A. Harper,
  • Joanne Calder and
  • Aurelie Laugraud

11 May 2016

Here we report the draft genome of Yersinia entomophaga type strain MH96T. The genome shows 93.8% nucleotide sequence identity to that of Yersinia nurmii type strain APN3a-cT, and comprises a single chromosome of approximately 4,275,531 bp. In silico...

  • Article
  • Open Access
23 Citations
8,784 Views
16 Pages

Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4

  • Lorena M. Durán-Riveroll,
  • Allan D. Cembella,
  • Christine J. Band-Schmidt,
  • José J. Bustillos-Guzmán and
  • José Correa-Basurto

6 May 2016

Saxitoxin (STX) and its analogs are paralytic alkaloid neurotoxins that block the voltage-gated sodium channel pore (Nav), impeding passage of Na+ ions into the intracellular space, and thereby preventing the action potential in the peripheral nervou...

  • Article
  • Open Access
15 Citations
6,448 Views
11 Pages

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

  • Fernando Lazcano-Pérez,
  • Héctor Castro,
  • Isabel Arenas,
  • David E. García,
  • Ricardo González-Muñoz and
  • Roberto Arreguín-Espinosa

5 May 2016

The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P. caribaeorum venom on voltage-gated...

  • Feature Paper
  • Article
  • Open Access
38 Citations
9,712 Views
15 Pages

5 May 2016

Micrurus clarki is an uncommon coral snake distributed from the Southeastern Pacific of Costa Rica to Western Colombia, for which no information on its venom could be found in the literature. Using a ‘venomics’ approach, proteins of at least nine fam...

  • Addendum
  • Open Access
3,840 Views
1 Page

5 May 2016

The authors wish to add the first affiliation address “Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science, Jiangnan University” to the correspondence author, Lili Tang’s affiliations on the first page of their paper publish...

  • Review
  • Open Access
67 Citations
13,266 Views
13 Pages

Toxin-Antitoxin Systems of Staphylococcus aureus

  • Christopher F. Schuster and
  • Ralph Bertram

5 May 2016

Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxi...

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Toxins - ISSN 2072-6651