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Toxins, Volume 16, Issue 6

2024 June - 52 articles

Cover Story: Ricin is a highly toxic plant protein that was misused as a bioterror and warfare agent in the past. The European consortium EuroBioTox was set up to establish, validate, and train detection and identification methods to be prepared for potential future incidences with this biotoxin. To enable standardised analyses, a reference material of ricin was produced, characterised and certified. In this study, N-glycan structures, and proportions, including their loci and occupancy, were investigated. The N-glycan profiles and amino acid sequences were compared with ricin from various preparations, cultivars, and isoforms. This detailed characterisation reveals ricin’s molecular features and variable attributes across cultivars, providing unique fingerprints for biotoxin origin determination. View this paper
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Articles (52)

  • Feature Paper
  • Article
  • Open Access
7 Citations
3,185 Views
24 Pages

The Clot Thickens: Differential Coagulotoxic and Cardiotoxic Activities of Anguimorpha Lizard Venoms

  • James Dobson,
  • Abhinandan Chowdhury,
  • Jeremie Tai-A-Pin,
  • Harold van der Ploeg,
  • Amber Gillett and
  • Bryan G. Fry

20 June 2024

Despite their evolutionary novelty, lizard venoms are much less studied in comparison to the intense research on snake venoms. While the venoms of helodermatid lizards have long been assumed to be for defensive purposes, there is increasing evidence...

  • Brief Report
  • Open Access
4 Citations
2,825 Views
10 Pages

Botulinum Toxin and Deep Brain Stimulation in Dystonia

  • Julia Carvalhinho Carlos de Souza,
  • Ananda Carolina Moraes Falcone,
  • Renata Montes Garcia Barbosa,
  • Miriam Carvalho Soares,
  • Renato P. Munhoz,
  • Marina Farah,
  • Tamine Capato,
  • Sara Carvalho Barbosa Casagrande,
  • Marcela Ferreira Cordellini and
  • Rubens Gisbert Cury
  • + 4 authors

20 June 2024

Deep Brain Stimulation (DBS) is a recognized treatment for different dystonia subtypes and has been approved by the Food and Drug Administration (FDA) since 2003. The European Federation of Neurological Societies (EFNS) and the International Parkinso...

  • Article
  • Open Access
1,697 Views
12 Pages

Exploring the Efficacy of Using Geotrichum fermentans, Rhodotorula rubra, Kluyveromyce marxiamus, Clay Minerals, and Walnut Nutshells for Mycotoxin Remediation

  • Gintarė Vaičiulienė,
  • Jurgita Jovaišienė,
  • Rimvydas Falkauskas,
  • Algimantas Paškevičius,
  • Neringa Sutkevičienė,
  • Audronė Rekešiūtė,
  • Šarūnė Sorkytė and
  • Violeta Baliukonienė

20 June 2024

The aim of this study was to evaluate the effectiveness of nine different biological compounds to reduce mycotoxins concentrations. The hypothesis of this study was that a static in vitro gastrointestinal tract model, as an initial screening tool, ca...

  • Article
  • Open Access
6 Citations
2,571 Views
17 Pages

19 June 2024

Despite the fact that the first red tide reported on the coasts of the Iberian Peninsula was due to Lingulodinium polyedra, knowledge about their frequency and, particularly, about the environmental conditions contributing to bloom initiation is stil...

  • Article
  • Open Access
4 Citations
5,200 Views
18 Pages

19 June 2024

(1) Background: At present, the only potency assay approved in China for the in-country testing of botulinum toxin type A for injection products is the mouse bioassay (MBA). The Chinese market for neurotoxin products is rapidly expanding, but MBAs ar...

  • Article
  • Open Access
7 Citations
3,315 Views
19 Pages

Assessment of Mycotoxin Exposure and Associated Risk in Pregnant Dutch Women: The Human Biomonitoring Approach

  • Hannah P. McKeon,
  • Marloes A. A. Schepens,
  • Annick D. van den Brand,
  • Marjolein H. de Jong,
  • Marleen M. H. J. van Gelder,
  • Marijn L. Hesselink,
  • Marta M. Sopel and
  • Marcel J. B. Mengelers

18 June 2024

Mycotoxins are toxic secondary metabolites produced by various fungi that can contaminate food crops, which, in turn, may lead to human exposure. Chronic exposure to mycotoxins can cause adverse health effects including reproductive and developmental...

  • Review
  • Open Access
9 Citations
3,469 Views
18 Pages

Biocontrol of Occurrence Ochratoxin A in Wine: A Review

  • Slaven Zjalic,
  • Ksenija Markov,
  • Jelena Loncar,
  • Zeljko Jakopovic,
  • Marzia Beccaccioli and
  • Massimo Reverberi

17 June 2024

Viticulture has been an important economic sector for centuries. In recent decades, global wine production has fluctuated between 250 and almost 300 million hectoliters, and in 2022, the value of wine exports reached EUR 37.6 billion. Climate change...

  • Article
  • Open Access
4 Citations
4,030 Views
23 Pages

Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model

  • Jaffer Alsolaiss,
  • Gail Leeming,
  • Rachael Da Silva,
  • Nessrin Alomran,
  • Nicholas R. Casewell,
  • Abdulrazaq G. Habib,
  • Robert A. Harrison and
  • Cassandra M. Modahl

17 June 2024

Snakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models, severe local envenoming, defined by morbidity-causing local tissue necrosis, remains poo...

  • Article
  • Open Access
1 Citations
2,499 Views
15 Pages

Comparative Analysis of Maize Physico-Chemical Parameters and Mycotoxin Levels in Dual Environments

  • Bruna Carbas,
  • Sílvia Barros,
  • Andreia Freitas,
  • Ana Sanches Silva and
  • Carla Brites

17 June 2024

Maize (Zea mays L.) stands as a vital staple food globally, holding significant nutritional and economic value. However, its susceptibility to mycotoxin contamination under stressful environmental conditions poses a considerable concern. This study a...

  • Review
  • Open Access
4 Citations
2,870 Views
21 Pages

Grass–Endophyte Interactions and Their Associated Alkaloids as a Potential Management Strategy for Plant Parasitic Nematodes

  • Nyambura G. Mwangi,
  • Mark Stevens,
  • Alistair J. D. Wright,
  • Simon G. Edwards,
  • Martin C. Hare and
  • Matthew A. Back

15 June 2024

Claviceptaceous endophytic fungi in the genus Epichloë mostly form a symbiotic relationship with cool-season grasses. Epichloë spp. are capable of producing bioactive alkaloids such as peramines, lolines, ergot alkaloids, and indole-diterpe...

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Toxins - ISSN 2072-6651