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Toxins, Volume 14, Issue 7

July 2022 - 86 articles

Cover Story: Antivenoms are life-saving snakebite therapeutics directed against crude venom, but the extensive venom toxin variation among snake species restricts their geographical utility. In this study, the authors explore the value of using specific snake venom serine protease toxins, recombinantly expressed in mammalian HEK293F cells, as immunogens for generating antibodies directed towards a specific toxin class. Recombinant ancrod, RVV-V, and batroxobin were used to generate murine antibodies, which were shown to bind to and inhibit the fibrinogenolytic activity of the toxin immunogens and crude venoms. These findings strengthen the case for the use of recombinant toxins as supplemental immunogens to stimulate focused and desirable antibody responses capable of neutralizing the specific venom-induced pathological effects associated with snakebites. View this paper
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Articles (86)

  • Article
  • Open Access
11 Citations
4,817 Views
18 Pages

A First Look at the Inhibitory Potential of Urospatha sagittifolia (Araceae) Ethanolic Extract for Bothrops atrox Snakebite Envenomation

  • Antonio L. Vera-Palacios,
  • Juan D. Sacoto-Torres,
  • Josselin A. Hernández-Altamirano,
  • Andres Moreno,
  • Maria C. Peñuela-Mora,
  • David Salazar-Valenzuela,
  • Noroska G. S. Mogollón and
  • José R. Almeida

17 July 2022

Bothrops atrox snakebites are a relevant problem in the Amazon basin. In this biodiverse region, the ethnomedicinal approach plays an important role as an alternative to antivenom therapy. Urospatha sagittifolia (Araceae) is a plant used for this pur...

  • Case Report
  • Open Access
2 Citations
6,333 Views
5 Pages

Envenoming by a Marine Blood Worm (Glycera)

  • Daniela M. Durkin,
  • Alison N. Young,
  • Kent Khtikian,
  • Zuzana Karjala,
  • Arin L. Isenstein,
  • Bryan G. Fry and
  • Matthew R. Lewin

17 July 2022

Bites from venomous marine annelid ‘bloodworms’ (e.g., Glycera spp.) do not appear to have been described in the medical literature despite being seemingly well-known to bait diggers and fishermen. The few laboratory study reports describ...

  • Case Report
  • Open Access
9 Citations
2,862 Views
9 Pages

Medical Management after Lancehead Snakebite in North Amazon: A Case Report of Long-Term Disability

  • Isadora S. Oliveira,
  • Carla B. Ananias,
  • Jilvando M. Medeiros,
  • Michelle V. S. Franco,
  • Isabela G. Ferreira,
  • Felipe A. Cerni,
  • Eliseu A. Sandri,
  • Wuelton M. Monteiro and
  • Manuela B. Pucca

16 July 2022

Snakebites are a major public health problem in indigenous communities in Brazil, leading to acute local and systemic damage with resulting deficiencies. Long-term musculoskeletal disabilities related to snakebites have been a neglected area of resea...

  • Article
  • Open Access
13 Citations
4,862 Views
32 Pages

Cocktails of Mycotoxins, Phytoestrogens, and Other Secondary Metabolites in Diets of Dairy Cows in Austria: Inferences from Diet Composition and Geo-Climatic Factors

  • Felipe Penagos-Tabares,
  • Ratchaneewan Khiaosa-ard,
  • Marlene Schmidt,
  • Eva-Maria Bartl,
  • Johanna Kehrer,
  • Veronika Nagl,
  • Johannes Faas,
  • Michael Sulyok,
  • Rudolf Krska and
  • Qendrim Zebeli

15 July 2022

Dairy production is a pivotal economic sector of Austrian and European agriculture. Dietary toxins and endocrine disruptors of natural origin such as mycotoxins and phytoestrogens can affect animal health, reproduction, and productivity. This study c...

  • Article
  • Open Access
11 Citations
3,621 Views
17 Pages

15 July 2022

It is widely accepted that eutrophication has played an important role in the formation of harmful cyanobacterial blooms in recent decades, which impacts water quality and ecological environment and causes huge economic losses. Algicidal bacteria hav...

  • Article
  • Open Access
6 Citations
3,312 Views
10 Pages

Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?

  • Mst Shamima Parvin,
  • Marcel Hrubša,
  • Jaka Fadraersada,
  • Alejandro Carazo,
  • Jana Karlíčková,
  • Lucie Cahlíková,
  • Jakub Chlebek,
  • Kateřina Macáková and
  • Přemysl Mladěnka

15 July 2022

Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions. As bleeding was suggested to be a side effect of the isoquinoline alkaloid berberine, w...

  • Article
  • Open Access
7 Citations
3,321 Views
12 Pages

Insights into the Cardiotoxic Effects of Veratrum Lobelianum Alkaloids: Pilot Study

  • Amir Taldaev,
  • Roman P. Terekhov,
  • Elizaveta V. Melnik,
  • Maria V. Belova,
  • Sergey V. Kozin,
  • Andrey A. Nedorubov,
  • Tatyana Ya. Pomerantseva and
  • Galina V. Ramenskaya

15 July 2022

Jervine, protoveratrine A (proA), and protoveratrine B (proB) are Veratrum alkaloids that are presented in some remedies obtained from Veratrum lobelianum, such as Veratrum aqua. This paper reports on a single-center pilot cardiotoxic mechanism study...

  • Article
  • Open Access
9 Citations
3,367 Views
15 Pages

Divergent Specialization of Simple Venom Gene Profiles among Rear-Fanged Snake Genera (Helicops and Leptodeira, Dipsadinae, Colubridae)

  • Peter A. Cerda,
  • Jenna M. Crowe-Riddell,
  • Deise J. P. Gonçalves,
  • Drew A. Larson,
  • Thomas F. Duda and
  • Alison R. Davis Rabosky

15 July 2022

Many venomous animals express toxins that show extraordinary levels of variation both within and among species. In snakes, most studies of venom variation focus on front-fanged species in the families Viperidae and Elapidae, even though rear-fanged s...

  • Review
  • Open Access
16 Citations
4,167 Views
21 Pages

15 July 2022

Cereals are of utmost importance for the nutrition of infants and children, as they provide important nutrients for their growth and development and, in addition, they are easily digestible, being the best choice for the transition from breast milk/i...

  • Review
  • Open Access
6 Citations
3,287 Views
12 Pages

15 July 2022

Owing to their low minimal environmental risk and other ethical considerations, plant-derived sterilants are used to control rodent populations. However, the effects of plant-derived sterilants are not immediate, and their efficacy on rodent control...

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Toxins - ISSN 2072-6651