Next Article in Journal
Milk Exosomes Transfer Oligosaccharides into Macrophages to Modulate Immunity and Attenuate Adherent-Invasive E. coli (AIEC) Infection
Previous Article in Journal
An Online Cross-Sectional Survey of Complementary Feeding Practices during the COVID-19 Restrictions in Poland
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 13
Issue 9
10.3390/nu13093197
Review Report
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Associations between Postprandial Gut Hormones and Markers of Bone Remodeling

Nutrients 2021, 13(9), 3197; https://doi.org/10.3390/nu13093197
by Nina Wittorff Jensen 1,*,†, Kim Katrine Bjerring Clemmensen 1,†, Marie Møller Jensen 1,2, Hanne Pedersen 1, Kristine Færch 1,3, Lars Jorge Diaz 4, Jonas Salling Quist 1 and Joachim Størling 3,5
Reviewer 1: Anonymous
Reviewer 2:
Sarit Pal
Nutrients 2021, 13(9), 3197; https://doi.org/10.3390/nu13093197
Submission received: 20 August 2021 / Revised: 6 September 2021 / Accepted: 10 September 2021 / Published: 14 September 2021
(This article belongs to the Section Nutrition and Obesity)

Round 1

Reviewer 1 Report

The authors show an association between postprandial gut hormones and markers of bone remodelling in subjects after consumption of two different meals. This have been shown in earlier studies but with fewer timepoints.

-Please include power calculations for the number of study participants

-Please indicate statistics used for the base line measurements in table 2

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The work by Jensen et al is well articulated and topic of interest. With the human subject's data, they made a compelling case for their hypothesis. However, there is major revision required at this present form.

 

Major concern:

  1. Sample size: Significantly smaller sample size, inclusion criteria for the subjects needed to be described. To make the study unbiased different age groups with different sexes are required.
  2. Diet: Different dietary constituents can significantly alter the secretion of a host of different hormones which essentially can exhibit anabolic and catabolic implications. Therefore, the two different diets mentioned in the study should be explained a) what are their composition 2) what are the calorific values of those compositions

If possible incorporate diets such as high carbohydrate, high protein, and high fat to the subjects and explore the change in the level of GIP, GLP1,CTX and PINP. This could significantly enrich the information in the manuscript.

  1. Statistical significance is not indicated in the figure.
  2. What is the postprandial effect of other bone formation markers such as osteocalcin, alkaline phosphatase? Whether they have any associations with gut hormones such as GIP, GLP1/2? Please incorporate those aspects in the manuscript. In addition to evaluation of serum level, a secondary method of validation will be beneficial to solidify the authors’ claim.
  3. Is there any previous evidence/reference to monitor the timepoints until 240 mins? If authors can incorporate the reasoning why they included that could render a better perspective to the readers.
  4. Reference needed:

Line 172-175

Restructuring of the writing needed: Lines 194-196

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Back to TopTop