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Article
Peer-Review Record

WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors

Nutrients 2021, 13(9), 3108; https://doi.org/10.3390/nu13093108
by Nicholas J. D’Alonzo 1, Lin Qiu 2, Dorothy D. Sears 3,4,5,6, Vernon Chinchilli 2, Justin C. Brown 7, David B. Sarwer 8, Kathryn H. Schmitz 2 and Kathleen M. Sturgeon 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Nutrients 2021, 13(9), 3108; https://doi.org/10.3390/nu13093108
Submission received: 16 August 2021 / Revised: 1 September 2021 / Accepted: 1 September 2021 / Published: 4 September 2021
(This article belongs to the Special Issue Effect of Diet and Physical Activity on Cancer Prevention and Control)

Round 1

Reviewer 1 Report

The paper is clear and well written

I only have some minor remarks:

Page 2, lines 79-80: “This report is a secondary analysis examining the effects of the trial on biomarkers of breast cancer recurrence”. Please explain

Discussion

Lines 280-285: “Lifestyle intervention in the form of exercise and weight loss have utility to improve outcomes with respect to breast cancer survival, adverse sequelae of cancer/cancertreatment, and recurrence. Insulin and the insulin pathways are mechanistic contributors in breast cancer pathogenesis, which supports why women who exercise and maintain a healthy body habitus have improved outcomes. This study reinforces the current association between markers of insulin resistance and body composition”

These concepts should be better analyzed and appropriately referenced.

Author Response

Please see the attachment 

Author Response File: Author Response.docx

Reviewer 2 Report

Thank you very much for that interesting manuscript. I have have just two comments.

A flow chart of the study would be useful to the reader.

And did the authors also analysed breast cancer biomarker and checked the changes? Would be for the reader

Author Response

Please see the attachment 

Author Response File: Author Response.docx

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