WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors
Round 1
Reviewer 1 Report
The paper is clear and well written
I only have some minor remarks:
Page 2, lines 79-80: “This report is a secondary analysis examining the effects of the trial on biomarkers of breast cancer recurrence”. Please explain
Discussion
Lines 280-285: “Lifestyle intervention in the form of exercise and weight loss have utility to improve outcomes with respect to breast cancer survival, adverse sequelae of cancer/cancertreatment, and recurrence. Insulin and the insulin pathways are mechanistic contributors in breast cancer pathogenesis, which supports why women who exercise and maintain a healthy body habitus have improved outcomes. This study reinforces the current association between markers of insulin resistance and body composition”
These concepts should be better analyzed and appropriately referenced.
Author Response
Please see the attachment
Author Response File: Author Response.docx
Reviewer 2 Report
Thank you very much for that interesting manuscript. I have have just two comments.
A flow chart of the study would be useful to the reader.
And did the authors also analysed breast cancer biomarker and checked the changes? Would be for the reader
Author Response
Please see the attachment
Author Response File: Author Response.docx