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Open AccessArticle

Effect of Two Meal Replacement strategies on Cardiovascular Risk Parameters in Advanced Age Patients with Obesity and Osteoarthritis

1
Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 3, 47003 Valladolid, Spain
2
Instituto de Endocrinología y Nutrición (IENVA), Universidad de Valladolid, Av. Ramón y Cajal, 3, 47003 Valladolid, Spain
3
Servicio de Traumatología, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal, 3, 47003 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 976; https://doi.org/10.3390/nu12040976
Received: 28 February 2020 / Revised: 29 March 2020 / Accepted: 30 March 2020 / Published: 1 April 2020
Background and aims: Meal replacement diets consist of replacing one or more meals with an artificial nutritional supplement. The objective of this study was to compare the effect of one against two meal replacement strategies on body composition and cardiovascular risk parameters in patients with obesity. Methods: A randomized clinical trial was designed with a modified hypocaloric diet with an artificial nutritional preparation replacing one or two meals for three months in patients with obesity and osteoarthritis pending orthopedic surgery. An anthropometric evaluation and a measurement of the body composition were done with bioelectrical impedance measurement at the beginning and at three months. Results: A total of 112 patients were recruited. Fifty-two patients (46.4%) were randomized to one replacement and 60 patients (53.6%) to two meal replacements. Eighty-one patients (72.3%) were women, and the average age was 61 (11.03) years. The percentage of weight loss at three months was 8.27 (4.79)% (one meal replacement: 7.98 (5.97)%; two meal replacements: 8.50 (3.48)%; p = 0.56). A decrease in fat mass measured by the fat mass index (FMI) was detected (one meal replacement: −2.15 (1.45) kg/m2 vs. two meal replacements: −2.78 (2.55) kg/m2; p > 0.05), and a relative increase in fat-free mass was observed (one meal replacement: +3.57 (4.61)% vs. two meal replacements: +2.14 (4.45)%; p > 0.05). A decrease in HOMA-IR, systolic blood pressure (SBP), and total cholesterol was observed in both groups without differences between them. Conclusions: The substitution strategies of one or two meal replacements were effective in weight loss and fat mass decrease without differences between the two groups. An improvement in lipid parameters, glycemic control, and systolic blood pressure was observed without differences between strategies. View Full-Text
Keywords: obesity; osteoarthritis; meal replacement diet; cardiovascular risk obesity; osteoarthritis; meal replacement diet; cardiovascular risk
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MDPI and ACS Style

López-Gómez, J.J.; Izaola-Jauregui, O.; Primo-Martín, D.; Torres-Torres, B.; Gómez-Hoyos, E.; Ortolá-Buigues, A.; Martín-Ferrero, M.A.; De Luis-Román, D.A. Effect of Two Meal Replacement strategies on Cardiovascular Risk Parameters in Advanced Age Patients with Obesity and Osteoarthritis. Nutrients 2020, 12, 976. https://doi.org/10.3390/nu12040976

AMA Style

López-Gómez JJ, Izaola-Jauregui O, Primo-Martín D, Torres-Torres B, Gómez-Hoyos E, Ortolá-Buigues A, Martín-Ferrero MA, De Luis-Román DA. Effect of Two Meal Replacement strategies on Cardiovascular Risk Parameters in Advanced Age Patients with Obesity and Osteoarthritis. Nutrients. 2020; 12(4):976. https://doi.org/10.3390/nu12040976

Chicago/Turabian Style

López-Gómez, Juan J.; Izaola-Jauregui, Olatz; Primo-Martín, David; Torres-Torres, Beatriz; Gómez-Hoyos, Emilia; Ortolá-Buigues, Ana; Martín-Ferrero, Miguel A.; De Luis-Román, Daniel A. 2020. "Effect of Two Meal Replacement strategies on Cardiovascular Risk Parameters in Advanced Age Patients with Obesity and Osteoarthritis" Nutrients 12, no. 4: 976. https://doi.org/10.3390/nu12040976

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