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Article

Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans

1
Postgraduate Program in Human Nutrition, College of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília DF 70.910-900, Brazil
2
Unité de Nutrition Humaine, Université Clermont Auvergne, INRAE, UNH, F-63000 Clermont-Ferrand, France
3
Department of Internal Medicine, Division of Cardiovascular Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
4
Laboratory of Cellular Immunology, Faculty of Medicine, University of Brasilia, Brasilia DF 70.910-900, Brazil
5
Laboratory of Food Science, Embrapa Cerrados, Planaltina DF 73.310-970, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1104; https://doi.org/10.3390/nu12041104
Received: 14 March 2020 / Revised: 26 March 2020 / Accepted: 31 March 2020 / Published: 16 April 2020
(This article belongs to the Special Issue Dietary Intakes and Metabolic Disorders)
Background: Passiflora setacea (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans. Methods: Overweight male volunteers (n = 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2). Results: Insulin and homeostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine–cytokine receptor. Conclusion: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases. View Full-Text
Keywords: Passiflora setacea; bioactive compounds; phenolic compounds; cardiovascular diseases; nutrigenomics; gene expression; immune system; cytokines; insulin; HDL Passiflora setacea; bioactive compounds; phenolic compounds; cardiovascular diseases; nutrigenomics; gene expression; immune system; cytokines; insulin; HDL
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MDPI and ACS Style

Duarte, I.d.A.E.; Milenkovic, D.; Borges, T.K.d.S.; Rosa, A.J.d.M.; Morand, C.; Oliveira, L.d.L.d.; Costa, A.M. Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans. Nutrients 2020, 12, 1104. https://doi.org/10.3390/nu12041104

AMA Style

Duarte IdAE, Milenkovic D, Borges TKdS, Rosa AJdM, Morand C, Oliveira LdLd, Costa AM. Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans. Nutrients. 2020; 12(4):1104. https://doi.org/10.3390/nu12041104

Chicago/Turabian Style

Duarte, Isabella d.A.E., Dragan Milenkovic, Tatiana K.d.S. Borges, Artur J.d.M. Rosa, Christine Morand, Livia d.L.d. Oliveira, and Ana M. Costa. 2020. "Acute Effects of the Consumption of Passiflora setacea Juice on Metabolic Risk Factors and Gene Expression Profile in Humans" Nutrients 12, no. 4: 1104. https://doi.org/10.3390/nu12041104

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