Next Article in Journal
Reproducibility of A Non-Quantitative Food Frequency Questionnaire (62-Item FFQ-6) and PCA-Driven Dietary Pattern Identification in 13–21-Year-Old Females
Previous Article in Journal
Hypothalamic–Pituitary and Adipose Tissue Responses to the Effect of Resistin in Sheep: The Integration of Leptin and Resistin Signaling Involving a Suppressor of Cytokine Signaling 3 and the Long Form of the Leptin Receptor
Previous Article in Special Issue
Adherence to DASH-Style Dietary Pattern Impacts on Adiponectin and Clustered Metabolic Risk in Older Women
Open AccessArticle

The Interplay of Diet Quality and Alzheimer’s Disease Genetic Risk Score in Relation to Cognitive Performance Among Urban African Americans

1
Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program (IRP), National Institutes of Health, Baltimore, MD 21224, USA
2
Department of Behavioral Health and Nutrition, University of Delaware, Newark, DE 19716, USA
3
Biomedical Research Center, National Institute on Aging (NIA), 251 Bayview Blvd. Baltimore, MD 21224, USA
*
Author to whom correspondence should be addressed.
The authors have equal contribution to the manuscript.
Nutrients 2019, 11(9), 2181; https://doi.org/10.3390/nu11092181
Received: 26 July 2019 / Revised: 6 September 2019 / Accepted: 8 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue DASH Diet and Human Health)
We examined the interactive associations of poor diet quality and Alzheimer’s Disease (AD) genetic risk with cognitive performance among 304 African American adults (mean age~57 years) from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. In this cross-sectional study, selected participants had complete predictors and covariate data with 13 cognitive test scores as outcomes. Healthy Eating Index-2010 (HEI-2010), Dietary Approaches to Stop Hypertension (DASH), and mean adequacy ratio (MAR) were measured. A genetic risk score for AD in HANDLS (hAlzScore) was computed from 12 selected single nucleotide polymorphisms (SNPs). Our key hypotheses were tested using linear regression models. The hAlzScore was directly associated with poor performance in verbal memory (−0.4 ± 0.2, 0.01) and immediate visual memory (0.4 ± 0.2, 0.03) measured in seconds, in women only. The hAlzScore interacted synergistically with poorer diet quality to determine lower cognitive performance on a test of verbal fluency. Among numerous SNP × diet quality interactions for models of cognitive performance as outcomes, only one passed correction for multiple testing, namely verbal fluency. Our results suggest that improved diet quality can potentially modify performance on cognitive tests of verbal fluency among individuals with higher AD genetic risk. View Full-Text
Keywords: genetic risk score; diet quality; Alzheimer’s Diseases; cognitive function; working memory; African American; single nucleotide polymorphism; health disparities genetic risk score; diet quality; Alzheimer’s Diseases; cognitive function; working memory; African American; single nucleotide polymorphism; health disparities
Show Figures

Figure 1

MDPI and ACS Style

Hossain, S.; Beydoun, M.A.; Kuczmarski, M.F.; Tajuddin, S.; Evans, M.K.; Zonderman, A.B. The Interplay of Diet Quality and Alzheimer’s Disease Genetic Risk Score in Relation to Cognitive Performance Among Urban African Americans. Nutrients 2019, 11, 2181.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop