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Effect of Sleeve Gastrectomy on Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Content and Lipid Metabolism in the Blood Plasma and Liver of Obese Wistar Rats

1
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 15-222 Bialystok, Poland
2
Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
3
Department of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2174; https://doi.org/10.3390/nu11092174
Received: 10 July 2019 / Revised: 30 August 2019 / Accepted: 30 August 2019 / Published: 10 September 2019
Nowadays, obesity and its complications are heavy burdens to western civilization. Surgical procedures remain one of the available therapies for obesity and obesity-associated diseases treatment. Among them, sleeve gastrectomy is the most common bariatric procedure. Despite the well-established fact that sleeve gastrectomy results in significant weight loss, some of its other divergent effects still need to be established. To fulfill this knowledge gap, we examined whether sleeve gastrectomy affects lipid metabolism in the plasma and liver of obese rats. We demonstrated that chronic high-fat diet feeding led to an increment in the level of Proprotein Convertase Subtilisin/Kexin (PCSK)—a regulator of plasma cholesterol concentration—in the liver, which was decreased after the gastrectomy. Moreover, we noticed significant increases in both plasma and liver contents of free fatty acids, diacylgycerides and triacylglycerides in the obese animals, with their reduction after the bariatric surgery. In conclusion, we revealed, presumably for the first time, that sleeve gastrectomy affects lipid metabolism in the liver of obese rats. View Full-Text
Keywords: sleeve gastrectomy; obesity; proprotein convertase subtilisin/kexin type 9; free fatty acids; diacylglycerides; triacylglycerides sleeve gastrectomy; obesity; proprotein convertase subtilisin/kexin type 9; free fatty acids; diacylglycerides; triacylglycerides
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Grzegorczyk, E.; Książek, M.; Kurek, K.; Łukaszuk, B.; Rosołowski, M.; Paszko, A.; Krzyżak, M.; Żendzian-Piotrowska, M. Effect of Sleeve Gastrectomy on Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Content and Lipid Metabolism in the Blood Plasma and Liver of Obese Wistar Rats. Nutrients 2019, 11, 2174.

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