The intensification of global urbanization has exacerbated the negative impact of atmospheric environmental factors in urban areas, thus threatening the sustainability of future urban development. In order to ensure the sustainability of urban atmospheric environments, exploring the changing laws of urban air quality, identifying highly polluted areas in cities, and studying the relationship between air quality and land use have become issues of great concern. Based on AQI data from 340 air quality monitoring stations and urban land use data, this paper uses inverse distance weight (IDW), Getis-Ord Gi*, and a negative binomial regression model to discuss the spatiotemporal variation of air quality in the main urban area of Lanzhou and its relationship with urban land use. The results show that urban air quality has characteristics of temporal and spatial differentiation and spatially has characteristics of agglomeration of cold and hot spots. There is a close relationship between urban land use and air quality. Industrial activities, traffic pollution, and urban construction activities are the most important factors affecting urban air quality. Green spaces can reduce urban pollution. The impact of land use on air quality has a seasonal effect.
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