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Clinics and Practice, Volume 16, Issue 5

2026 May - 16 articles

Cover Story: Celiac disease presents with a broad spectrum of intestinal and extraintestinal manifestations, often leading to delayed diagnosis and underrecognition in adults. This study compares the clinical, serological, and histopathological profiles of newly diagnosed patients with those following a gluten-free diet. The findings highlight the persistence of certain symptoms despite dietary treatment, the high prevalence of seronegative cases, and the association of active disease with histopathological severity and hematological abnormalities such as thrombocytosis. These results emphasize the heterogeneity of adult celiac disease and the importance of comprehensive clinical and histopathological evaluation in both diagnosis and follow-up. View this paper
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Articles (16)

  • Article
  • Open Access
401 Views
13 Pages

Background/Objectives: Metabolic dysfunction-associated steatohepatitis (MASH) is frequently accompanied by disturbances in coagulation and metabolic homeostasis, partly related to impaired handling of vitamin K-dependent pathways. Although vitamin K...

  • Systematic Review
  • Open Access
1 Citations
2,069 Views
22 Pages

Background: Growth disorders, including central precocious puberty and delayed puberty, can significantly affect linear growth, skeletal maturation, metabolic regulation, and psychosocial development during childhood and adolescence. This systematic...

  • Case Report
  • Open Access
1,888 Views
10 Pages

Intestinal Neuronal Dysplasia Type B as Rare Organic Cause of Refractory Constipation in Adults: A Case Report and Literature Review

  • Rosana Troskot Perić,
  • Branko Bakula,
  • Nensi Orlandini,
  • Tomislav Pavlović,
  • Mato Perić and
  • Gabrijela Stanić

Background: Intestinal neuronal dysplasia type B is an entity characterized by disturbances in the enteric plexus, it most often occurs in childhood and can appear as an isolated disease or in combination with other neuropathies. The main symptoms ar...

  • Article
  • Open Access
413 Views
13 Pages

Objective: To develop an individual assessment for patients suffering from medication-related osteonecrosis of the jaw (MRONJ), we developed a scoring system that integrates anamnestic, clinical, and radiological parameters to facilitate the process...

(This article belongs to the Section Dentistry and Oral Medicine)
  • Review
  • Open Access
2 Citations
877 Views
15 Pages

A Clinical Decision Support System for Post-Surgical Cardiovascular Remote Monitoring

  • Charalampia Pylarinou,
  • Francesk Mulita,
  • Efstratios Koletsis,
  • Vasileios Leivaditis,
  • Elias Liolis,
  • Lefteris Gortzis and
  • Dimosthenis Mavrilas

Background: Post-surgical cardiovascular monitoring places a heavy information burden on clinical teams, requiring the rapid synthesis of patient history, intraoperative data, monitoring streams, and surgical outcome evidence. Existing clinical decis...

  • Systematic Review
  • Open Access
2,064 Views
12 Pages

An Update on Umbilical Cord Abnormalities and Associated Thrombosis: A Systematic Review

  • Marco La Verde,
  • Eleonora Braca,
  • Antonio Cerillo,
  • Maria Fatigati,
  • Pasquale De Franciscis,
  • Davide Pisani,
  • Mario Fordellone,
  • Mariavictoria De Simone,
  • Carlo Pietro Campobasso and
  • Alessandro Feola

Background and objective: Umbilical cord abnormalities (UCAs) such as hypercoiling, velamentous or marginal cord insertion, or reduced Wharton’s jelly are associated with umbilical thrombosis. UCAs increase the risk of vascular obstruction and...

(This article belongs to the Section Reproductive Medicine and Women’s Health)
  • Article
  • Open Access
1 Citations
738 Views
12 Pages

Digital Access for Screens and Smiles: Telehealth Use and Dental Care Access in the U.S.

  • Gulzar Shah,
  • Anjana Kalathimekkattu,
  • Indira Karibayeva and
  • Bobbie J. Newell

Background/Objectives: Cost-related delays hinder access to dental care in the United States, while the growing use of telehealth has an uncertain impact on population-level access to dental services. The study examined factors associated with cost-r...

(This article belongs to the Section Dentistry and Oral Medicine)
  • Article
  • Open Access
2,143 Views
16 Pages

Efficacy and Safety of Glycerol Lidocaine Ear Drops in the Non-Antibiotic Treatment of Otitis Externa Symptoms—An Observational Study

  • Maria Sobol,
  • Ewelina Sielska-Badurek,
  • Mariusz Cięciara,
  • Artur Wrzosek,
  • Justyna Tomaszewska and
  • Beata Roman

Purpose: The aim of this study was to investigate the safety and efficacy, as well as relief of symptoms after regular use, of 0.5% lidocaine hydrochloride solution in anhydrous glycerol (Auridol) in the form of ear drops, in patients with symptoms o...

  • Article
  • Open Access
1,262 Views
16 Pages

Development of a Core Set of Nursing-Sensitive Patient Outcomes in Intensive Care Units: A Delphi Consensus Study

  • Luciano Cellura,
  • Anna Maria Grugnetti,
  • Stefano Gabriele Scaglia,
  • Attilio Quaini,
  • Silvia Natoli and
  • Giuseppina Grugnetti

Introduction/Aim: Nursing care constitutes a fundamental determinant of patient outcomes in intensive care units (ICUs); however, the absence of standardised nursing-sensitive indicators constrains the objective evaluation of care quality within this...

  • Article
  • Open Access
996 Views
17 Pages

Clinical and Histopathological Profile of Adults with Celiac Disease at Diagnosis and on a Gluten-Free Diet: A Cross-Sectional Observational Study

  • Elena Maria Domsa,
  • Ioana Para,
  • Adela Viviana Sitar Taut,
  • Teodora Atena Pop,
  • Elena Ofelia Mosteanu,
  • Laura Elena Gligor,
  • Mihaela Elvira Cîmpianu,
  • Antonia Gabriela Nitescu,
  • Viorel Lucian Marina and
  • Vasile Andreica
  • + 1 author

Background/Objectives: Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by gluten ingestion in genetically predisposed individuals, with a highly heterogeneous clinical presentation encompassing both intestinal and extraintestin...

  • Article
  • Open Access
494 Views
13 Pages

Prognostic Significance of Dynamic Free T3 Changes in Critically Ill Patients

  • Yakup Özgüngör,
  • Burak Emre Gilik,
  • Emre Karagöz,
  • Hicret Yeniay,
  • Mensure Çakırgöz,
  • Özlem Melis Korkmaz Özgüngör,
  • İhsan Birol and
  • Sıla Seven

Background: Non-thyroidal illness syndrome is frequent in critically ill patients, but the prognostic value of dynamic changes in thyroid function tests remains unclear. This study evaluated whether serial measurements of thyroid-stimulating hormone...

(This article belongs to the Topic Hospitalization in Frail Patients: A Public Health Challenge)
  • Case Report
  • Open Access
2 Citations
1,467 Views
12 Pages

Steroid Refractory and Plasma Exchange Partially Responsive Longitudinally Extensive Transverse Myelitis Due to Tumor Necrosis Factor-Alpha (Etanercept): A Case Report

  • Jelena Stojsavljevic,
  • Rafael R. Perez,
  • Emilia Petcu,
  • Celestine Odenigbo,
  • Cristian Madrid,
  • Igor Dumic and
  • Charles W. Nordstrom

Background: Acute transverse myelitis (ATM) is an inflammatory disorder of the spinal cord with heterogeneous etiologies, including autoimmune, infectious, paraneoplastic, and drug-induced causes. Tumor necrosis factor-alpha (TNF-α) inhibitors...

  • Article
  • Open Access
1 Citations
2,119 Views
13 Pages

Efficacy of Combining Kegel Exercises with EMS-Based Pelvic Floor Muscle Electrostimulation in Postmenopausal Women with Involuntary Urinary Leakage

  • Lucian Șerbănescu,
  • Sebastian Mirea,
  • Paris Ionescu,
  • Ionuț Iorga,
  • Traian-Virgiliu Surdu,
  • Vadym Rotar,
  • Stere Popescu,
  • Elena Mocanu,
  • Luana Alexandrescu and
  • Radu-Andrei Baz
  • + 1 author

Background/Objectives: Urinary incontinence (UI) is a frequent condition in postmenopausal women and is associated with a substantial negative impact on quality of life. Conservative management can include pelvic floor muscle training (PFMT) and high...

  • Article
  • Open Access
1 Citations
1,493 Views
14 Pages

Patterns of Enteral Feeding, Feeding Intolerance, and Mortality in Traumatic Brain Injury: An Observational Study

  • Hasan M. Al-Dorzi,
  • Abdulaziz R. Al-Qwizani,
  • Turki F. Al-Saikhan,
  • Yousef Alshahwan,
  • Bandar F. Bindayel,
  • Raed Alharthi and
  • Raymond Khan

Background: Patients with traumatic brain injury (TBI) are often underfed and frequently experience enteral feeding (EF) intolerance. We examined the association between EF timing, caloric intake and EF intolerance, and mortality. Methods: We retrosp...

  • Article
  • Open Access
1 Citations
946 Views
16 Pages

Objectives: Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, and cardiometabolic comorbidity, have been increasingly associated with cognitive impairment and dementia. These associations, however, remain underexplored and under...

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Clin. Pract. - ISSN 2039-7283