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Journal of Xenobiotics, Volume 15, Issue 1

February 2025 - 33 articles

Cover Story: Models for NOEL (No Observed Effect Level) and NOEC (No Observed Effect Concentration) related to the long-term/reproduction toxicity of various organic pesticides are built up, evaluated, and compared with similar models proposed in the literature. The data have been obtained from the EFSA OpenFoodTox database, collecting only data for the Bobwhite quail (Colinus virginianus). Models have been developed using the CORAL program, which can be used to develop quantitative structure-property/activity relationships (QSPRs/QSARs), and the Monte Carlo method for the optimization of the model. The software provided a model which may be considered useful for the practice. The determination coefficient of the best models for the external validation set was 0.665. View this paper
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Articles (33)

  • Article
  • Open Access
2,056 Views
14 Pages

New Standardized Procedure to Extract Glyphosate and Aminomethylphosphonic Acid from Different Matrices: A Kit for HPLC-UV Detection

  • Francesco Chiara,
  • Sarah Allegra,
  • Elisa Arrigo,
  • Daniela Di Grazia,
  • Francesco Maximillian Anthony Shelton Agar,
  • Raluca Elena Abalai,
  • Sara Gilardi,
  • Silvia De Francia and
  • Daniele Mancardi

2 February 2025

Background: Glyphosate has been extensively used as herbicide since the early 1970s. The daily exposure limit is set at 0.3 mg/kg bw/d in Europe and 1.75 mg/kg bw/d in the USA. Among its derivatives, aminomethylphosphonic acid is the most stable and...

  • Article
  • Open Access
1 Citations
1,263 Views
16 Pages

Remodeling of Embryo Architecture in Response to Vanadium and Increased Temperatures: From Morphometric to Molecular Changes

  • Roberto Chiarelli,
  • Chiara Martino,
  • Rosaria Scudiero,
  • Alessio Terenzi and
  • Fabiana Geraci

1 February 2025

The study of ecotoxicity induced by vanadium (V) represents an area of increasing interest due to the growing use of V in both the industrial and pharmaceutical areas. This leads to its introduction into water environments, marking a developing probl...

  • Review
  • Open Access
2 Citations
1,302 Views
23 Pages

1 February 2025

The soil environment has been considered capable of storing toxic substances without serious consequences for the inhabitants since plants are able to bioaccumulate pollutants without compromising their survival. The application of chemicals to incre...

  • Article
  • Open Access
2 Citations
5,834 Views
20 Pages

Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver

  • Kari A. Gaither,
  • Guihua Yue,
  • Dilip Kumar Singh,
  • Julia Trudeau,
  • Kannapiran Ponraj,
  • Nadezhda Y. Davydova,
  • Philip Lazarus,
  • Dmitri R. Davydov and
  • Bhagwat Prasad

31 January 2025

In this study, to better understand the mechanisms of the profound impact of alcohol consumption on drug pharmacokinetics, efficacy, and toxicity, we characterized the alcohol-induced changes in the ensemble of drug-metabolizing enzymes and transport...

  • Review
  • Open Access
6 Citations
5,336 Views
25 Pages

The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier

  • Abdus Sabur,
  • Angkan Khan,
  • B. Borphukan,
  • Abdur Razzak,
  • M. Salimullah and
  • Muslima Khatun

25 January 2025

The lack of new antibacterial medicines and the rapid rise in bacterial resistance to antibiotics pose a major threat to individuals and healthcare systems. Despite the availability of various antibiotics, bacterial resistance has emerged for almost...

  • Article
  • Open Access
1 Citations
1,375 Views
10 Pages

Apis mellifera as a Model Species to Evaluate Toxicological Effects of Fungicides Used in Vineyard Agroecosystems

  • Tommaso Campani,
  • Ginevra Manieri,
  • Ilaria Caliani,
  • Agata Di Noi and
  • Silvia Casini

21 January 2025

Agroecosystems provide habitats, food, and water for many pollinators and insects, but they are also heavily exposed to threats from the widespread use of pesticides and fertilizers. Managed honeybees and wild bees encounter pesticides in vineyards b...

  • Article
  • Open Access
1 Citations
1,646 Views
14 Pages

Distribution of Environmental Phenols into Follicular Fluid and Urine of Women Attending Infertility Clinic

  • Anna Klimowska,
  • Joanna Jurewicz,
  • Michał Radwan,
  • Paweł Radwan,
  • Paweł Pol and
  • Bartosz Wielgomas

21 January 2025

Infertility and environmental pollution are two globally prevalent and related issues. To explore women’s reproductive health, the composition of follicular fluid (FF) has been studied and it was found that changes to its composition, including...

  • Article
  • Open Access
5 Citations
2,976 Views
27 Pages

19 January 2025

Type 2 diabetes mellitus (T2DM) is an intricate disease correlated with many metabolic deregulations, including disordered glucose metabolism, oxidative stress, inflammation, and cellular apoptosis due to hepatic gluconeogenesis aberrations. However,...

  • Article
  • Open Access
2 Citations
16,681 Views
18 Pages

The Issue of “Smart Drugs” on the Example of Modafinil: Toxicological Analysis of Evidences and Biological Samples

  • Karolina Nowak,
  • Agnieszka Chłopaś-Konowałek,
  • Paweł Szpot and
  • Marcin Zawadzki

17 January 2025

Cognitive enhancement through stimulants such as modafinil is becoming increasingly popular, with many individuals using prescription stimulants for non-medical purposes to improve alertness, attention, and mood. The misuse of such substances has rai...

  • Article
  • Open Access
6 Citations
2,652 Views
20 Pages

Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity

  • Gracia Luque,
  • Pilar Ortiz,
  • Alfonso Torres-Sánchez,
  • Alicia Ruiz-Rodríguez,
  • Ana López-Moreno and
  • Margarita Aguilera

17 January 2025

Dietary exposure to the plasticiser bisphenol A (BPA), an obesogenic and endocrine disruptor from plastic and epoxy resin industries, remains prevalent despite regulatory restriction and food safety efforts. BPA can be accumulated in humans and anima...

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J. Xenobiot. - ISSN 2039-4713