Impact of Nutrition and the Environment on Human Metabolism

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Guest Editor
Biology Center, Biochemistry Department, Lille University Hospital, 59000 Lille, France
Interests: biochemistry; nitrous oxide; biomarkers; human metabolism; human genetics; genomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human metabolism is influenced by a wide range of factors, including diet and environmental exposures. This Special Issue aims to explore the complex mechanisms by which nutrition, environmental factors, and their interactions shape metabolic processes and influence human health. We invite original research articles, reviews, clinical studies, and experimental studies that examine the impact of various dietary components (micronutrients, macronutrients, specific diets) and environmental factors (pollutants, contaminants, oxidative stress) on metabolic pathways. Submissions may also address the implications of these factors in the development of metabolic, cardiovascular, neurodegenerative, and other health-related disorders. We particularly encourage interdisciplinary studies that integrate innovative approaches and highlight recent advances in understanding the nutrition-environment interplay.

Dr. Guillaume Grzych
Guest Editor

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Keywords

  • human metabolism
  • nutrition
  • environment
  • health
  • metabolic disorders
  • oxidative stress
  • dietary patterns
  • environmental contaminants
  • cardiovascular health
  • interdisciplinary approaches

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Published Papers (1 paper)

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Research

12 pages, 1468 KiB  
Article
The Impact of Trimethylamine N-Oxide on Atrial Fibrillation Presence in Patients with Cardiovascular Disease
by Cristian Marius Florea, Radu Ovidiu Rosu, Ioan Alexandru Minciuna, Gabriel Cismaru, Dana Pop, Ana-Maria Vlase, Iuliana Nenu and Gabriela Adriana Filip
J. Xenobiot. 2025, 15(1), 28; https://doi.org/10.3390/jox15010028 - 7 Feb 2025
Viewed by 734
Abstract
Background: Atrial fibrillation is the most common human heart rhythm disorder, yet its underlying causes remain largely unknown. Trimethylamine N-oxide (TMAO), a by-product derived from the gut microbiota contributed by red meat, has been linked to numerous cardiovascular and metabolic diseases. Aims [...] Read more.
Background: Atrial fibrillation is the most common human heart rhythm disorder, yet its underlying causes remain largely unknown. Trimethylamine N-oxide (TMAO), a by-product derived from the gut microbiota contributed by red meat, has been linked to numerous cardiovascular and metabolic diseases. Aims: This study aimed to evaluate the impact of serum TMAO levels on the occurrence of atrial fibrillation in patients with cardiovascular disease. Results: Utilizing a cross-sectional study design, fasting serum TMAO levels were measured and compared between 153 patients without cardiovascular disease and patients hospitalized for cardiovascular disease, stratified by the presence or absence of atrial fibrillation. While patients with more comorbidities had higher TMAO overall, the TMAO levels were not significantly different between cardiovascular disease patients with and without atrial fibrillation (p = 0.57). Moreover, there was no difference between atrial fibrillation progression phenotypes (p = 0.27). In multivariate analysis, a significant association was found with atherosclerotic cardiovascular disease (p = 0.04) and chronic kidney disease (p < 0.001), but there was no significant association between TMAO and atrial fibrillation (p = 0.9). Conclusions: Serum TMAO levels are not associated with the occurrence of atrial fibrillation and disease progression phenotypes in patients with cardiovascular disease, but are associated with ASCVD and CKD. Full article
(This article belongs to the Special Issue Impact of Nutrition and the Environment on Human Metabolism)
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