Abstract
The duodenum is an exceptional location of the primary squamous cell carcinoma. Few cases have been reported in the literature. We report here the second case of this tumor in this exceptional location (transverse duodenum) in a sixty years-old women without medical history, who consulted for epigastric pain since 3 months, associated with an episode of melena and weight loss of 5 kg. The assessement and pathological study of endoscopic specimen confirms the squamous cell nature of the tumor. The treatment consisted of palliative chemotherapy with analgesic treatment.