Next Article in Journal
Palm to Finger Ulnar Sensory Nerve Conduction
Previous Article in Journal
Botulinum Neurotoxin Type A in Neurology: Update
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Neurology International
Volume 7
Issue 2
10.4081/ni.2015.5885
neurolint-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Amyotrophic Lateral Sclerosis: New Perpectives and Update

by
Marco Orsini
1,2,*,
Acary Bulle Oliveira
3,
Osvaldo J.M. Nascimento
1,
Carlos Henrique Melo Reis
1,
Marco Antonio Araujo Leite
1,
Jano Alves de Souza
1,
Camila Pupe
1,
Olivia Gameiro de Souza
1,
Victor Hugo Bastos
4,
Marcos R.G. de Freitas
1,
Silmar Teixeira
4,
Carlos Bruno
1,
Eduardo Davidovich
1 and
Benny Smidt
3
1
Neurology Department, Universidade Federal Fluminense, Rio de Janeiro
2
Programa de Mestrado em Ciências da Reabiitação – UNISUAM, Rio de Janeiro
3
Neurology Department, Universidade Federal de São Paulo – UNIFESP, São Paulo
4
Neuroscience Department, Universidade Federal do Piaiu, Parnaiba, Brazil
*
Author to whom correspondence should be addressed.
Neurol. Int. 2015, 7(2), 5885; https://doi.org/10.4081/ni.2015.5885
Submission received: 25 February 2015 / Revised: 25 February 2015 / Accepted: 15 June 2015 / Published: 24 September 2015

Abstract

Amyotrophic lateral sclerosis (ALS), Charcot’s disease or Lou Gehrig’s disease, is a term used to cover the spetrum of syndromes caracterized by progressive degeneration of motor neurons, a paralytic disorder caused by motor neuron degeneration. Currently, there are approximately 25,000 patients with ALS in the USA, with an average age of onset of 55 years. The incidence and prevalence of ALS are 1-2 and 4-6 per 100,000 each year, respectively, with a lifetime ALS risk of 1/600 to 1/1000. It causes progressive and cumulative physical disabilities, and leads to eventual death due to respiratory muscle failure. ALS is diverse in its presentation, course, and progression. We do not yet fully understand the causes of the disease, nor the mechanisms for its progression; thus, we lack effective means for treating this disease. In this chapter, we will discuss the diagnosis, treatment, and how to cope with impaired function and end of life based on of our experience, guidelines, and clinical trials. Nowadays ALS seems to be a more complex disease than it did two decades – or even one decade – ago, but new insights have been plentiful. Clinical trials should be seen more as experiments on pathogenic mechanisms. A medication or combination of medications that targets more than one pathogenic pathway may slow disease progression in an additive or synergistic fashion.
Keywords: amyotrophic lateral sclerosis; neurodegenerative diseases; diagnosis; treatment; rehabilitation amyotrophic lateral sclerosis; neurodegenerative diseases; diagnosis; treatment; rehabilitation

Share and Cite

MDPI and ACS Style

Orsini, M.; Oliveira, A.B.; Nascimento, O.J.M.; Reis, C.H.M.; Leite, M.A.A.; de Souza, J.A.; Pupe, C.; de Souza, O.G.; Bastos, V.H.; de Freitas, M.R.G.; et al. Amyotrophic Lateral Sclerosis: New Perpectives and Update. Neurol. Int. 2015, 7, 5885. https://doi.org/10.4081/ni.2015.5885

AMA Style

Orsini M, Oliveira AB, Nascimento OJM, Reis CHM, Leite MAA, de Souza JA, Pupe C, de Souza OG, Bastos VH, de Freitas MRG, et al. Amyotrophic Lateral Sclerosis: New Perpectives and Update. Neurology International. 2015; 7(2):5885. https://doi.org/10.4081/ni.2015.5885

Chicago/Turabian Style

Orsini, Marco, Acary Bulle Oliveira, Osvaldo J.M. Nascimento, Carlos Henrique Melo Reis, Marco Antonio Araujo Leite, Jano Alves de Souza, Camila Pupe, Olivia Gameiro de Souza, Victor Hugo Bastos, Marcos R.G. de Freitas, and et al. 2015. "Amyotrophic Lateral Sclerosis: New Perpectives and Update" Neurology International 7, no. 2: 5885. https://doi.org/10.4081/ni.2015.5885

APA Style

Orsini, M., Oliveira, A. B., Nascimento, O. J. M., Reis, C. H. M., Leite, M. A. A., de Souza, J. A., Pupe, C., de Souza, O. G., Bastos, V. H., de Freitas, M. R. G., Teixeira, S., Bruno, C., Davidovich, E., & Smidt, B. (2015). Amyotrophic Lateral Sclerosis: New Perpectives and Update. Neurology International, 7(2), 5885. https://doi.org/10.4081/ni.2015.5885

Article Metrics

Back to TopTop