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Neurology International
Volume 7
Issue 1
10.4081/ni.2015.5973
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Estimation of the Presence of Small Dense Lipoprotein Cholesterol in Acute Ischemic Stroke

by
Yasuhiro Manabe
1,*,
Ryuta Morihara
1,
Kosuke Matsuzono
1,
Yumiko Nakano
1,
Yoshiaki Takahashi
1,
Hisashi Narai
1,
Nobuhiko Omori
1 and
Koji Abe
2
1
Department of Neurology, National Hospital Organization Okayama Medical Center
2
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Japan
*
Author to whom correspondence should be addressed.
Neurol. Int. 2015, 7(1), 5973; https://doi.org/10.4081/ni.2015.5973
Submission received: 29 April 2015 / Accepted: 13 May 2015 / Published: 3 June 2015

Abstract

Small dense low-density lipoprotein (sdLDL) is an established risk factor in ischemic heart disease. However, its clinical significance in acute ischemic stroke (AIS) is uncertain. This study evaluates the prognostic value of the presence of sdLDL in patients with AIS by determining whether it contributes to clinical outcome or not. We studied 530 consecutive patients admitted within the first 48 hours after onset of ischemic stroke and 50 corresponding controls. Serum lipid parameters were measured on admission by standard laboratory methods. The percentage of AIS patients with sdLDL was significantly higher than the one of matched controls with sdLDL. Concerning comparisons between AIS patients with or without sdLDL, the percentages of males and patients with histories of smoking, hypertension, and cardiovascular disease were significantly higher in AIS patients with sdLDL. Concerning the grade of severity, modified Rankin Scale (mRS) on discharge was significantly higher in AIS patients with sdLDL. On logistic regression analysis, age (OR=2.29, P<0.001), male gender (OR=0.49, P<0.01), history of atrial fibrillation (OR=3.46, P<0.001), and the presence of sdLDL (OR=1.59, P<0.05) were significantly associated with poor prognosis (mRS on discharge >3). Our study showed that the presence of sdLDL might be independently associated with a poor prognosis after AIS.
Keywords: small dense low-density lipoprotein; acute ischemic stroke; poor prognosis small dense low-density lipoprotein; acute ischemic stroke; poor prognosis

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MDPI and ACS Style

Manabe, Y.; Morihara, R.; Matsuzono, K.; Nakano, Y.; Takahashi, Y.; Narai, H.; Omori, N.; Abe, K. Estimation of the Presence of Small Dense Lipoprotein Cholesterol in Acute Ischemic Stroke. Neurol. Int. 2015, 7, 5973. https://doi.org/10.4081/ni.2015.5973

AMA Style

Manabe Y, Morihara R, Matsuzono K, Nakano Y, Takahashi Y, Narai H, Omori N, Abe K. Estimation of the Presence of Small Dense Lipoprotein Cholesterol in Acute Ischemic Stroke. Neurology International. 2015; 7(1):5973. https://doi.org/10.4081/ni.2015.5973

Chicago/Turabian Style

Manabe, Yasuhiro, Ryuta Morihara, Kosuke Matsuzono, Yumiko Nakano, Yoshiaki Takahashi, Hisashi Narai, Nobuhiko Omori, and Koji Abe. 2015. "Estimation of the Presence of Small Dense Lipoprotein Cholesterol in Acute Ischemic Stroke" Neurology International 7, no. 1: 5973. https://doi.org/10.4081/ni.2015.5973

APA Style

Manabe, Y., Morihara, R., Matsuzono, K., Nakano, Y., Takahashi, Y., Narai, H., Omori, N., & Abe, K. (2015). Estimation of the Presence of Small Dense Lipoprotein Cholesterol in Acute Ischemic Stroke. Neurology International, 7(1), 5973. https://doi.org/10.4081/ni.2015.5973

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