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Neurology International
Volume 5
Issue 3
10.4081/ni.2013.e16
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

A Score Based on Screening Tests to Differentiate Mild Cognitive Impairment from Subjective Memory Complaints

by
Fábio Henrique de Gobbi Porto
1,*,
Lívia Spíndola
1,
Maira Okada de Oliveira
1,
Patrícia Helena Figuerêdo do Vale
1,
Marco Orsini
2,
Ricardo Nitrini
1 and
Sonia Maria Dozzi Brucki
1
1
Behavioral and Cognitive Neurology Unit, Department of Neurology, Cognitive Disorders Reference Center, das Clínicas Hospital, University of São Paulo
2
Neurology Department, Antonio Pedro University Hospital, Federal Fluminense University, Rio de Janeiro, Brazil
*
Author to whom correspondence should be addressed.
Neurol. Int. 2013, 5(3), e16; https://doi.org/10.4081/ni.2013.e16
Submission received: 14 December 2012 / Revised: 3 April 2013 / Accepted: 6 May 2013 / Published: 5 September 2013

Abstract

It is not easy to differentiate patients with mild cognitive impairment (MCI) from subjective memory complainers (SMC). Assessments with screening cognitive tools are essential, particularly in primary care where most patients are seen. The objective of this study was to evaluate the diagnostic accuracy of screening cognitive tests and to propose a score derived from screening tests. Elderly subjects with memory complaints were evaluated using the Mini Mental State Examination (MMSE) and the Brief Cognitive Battery (BCB). We added two delayed recalls in the MMSE (a delayed recall and a late-delayed recall, LDR), and also a phonemic fluency test of letter P fluency (LPF). A score was created based on these tests. The diagnoses were made on the basis of clinical consensus and neuropsychological testing. Receiver operating characteristic curve analyses were used to determine area under the curve (AUC), the sensitivity and specificity for each test separately and for the final proposed score. MMSE, LDR, LPF and delayed recall of BCB scores reach statistically significant differences between groups (P=0.000, 0.03, 0.001 and 0.01, respectively). Sensitivity, specificity and AUC were MMSE: 64%, 79% and 0.75 (cut off <29); LDR: 56%, 62% and 0.62 (cut off <3); LPF: 71%, 71% and 0.71 (cut off <14); delayed recall of BCB: 56%, 82% and 0.68 (cut off <9). The proposed score reached a sensitivity of 88% and 76% and specificity of 62% and 75% for cut off over 1 and over 2, respectively. AUC were 0.81. In conclusion, a score created from screening tests is capable of discriminating MCI from SMC with moderate to good accurancy.
Keywords: mild cognitive impairment; subjective memory complaints; screening cognitive test; diagnostic score mild cognitive impairment; subjective memory complaints; screening cognitive test; diagnostic score

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MDPI and ACS Style

de Gobbi Porto, F.H.; Spíndola, L.; de Oliveira, M.O.; do Vale, P.H.F.; Orsini, M.; Nitrini, R.; Dozzi Brucki, S.M. A Score Based on Screening Tests to Differentiate Mild Cognitive Impairment from Subjective Memory Complaints. Neurol. Int. 2013, 5, e16. https://doi.org/10.4081/ni.2013.e16

AMA Style

de Gobbi Porto FH, Spíndola L, de Oliveira MO, do Vale PHF, Orsini M, Nitrini R, Dozzi Brucki SM. A Score Based on Screening Tests to Differentiate Mild Cognitive Impairment from Subjective Memory Complaints. Neurology International. 2013; 5(3):e16. https://doi.org/10.4081/ni.2013.e16

Chicago/Turabian Style

de Gobbi Porto, Fábio Henrique, Lívia Spíndola, Maira Okada de Oliveira, Patrícia Helena Figuerêdo do Vale, Marco Orsini, Ricardo Nitrini, and Sonia Maria Dozzi Brucki. 2013. "A Score Based on Screening Tests to Differentiate Mild Cognitive Impairment from Subjective Memory Complaints" Neurology International 5, no. 3: e16. https://doi.org/10.4081/ni.2013.e16

APA Style

de Gobbi Porto, F. H., Spíndola, L., de Oliveira, M. O., do Vale, P. H. F., Orsini, M., Nitrini, R., & Dozzi Brucki, S. M. (2013). A Score Based on Screening Tests to Differentiate Mild Cognitive Impairment from Subjective Memory Complaints. Neurology International, 5(3), e16. https://doi.org/10.4081/ni.2013.e16

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