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Neurology International
Volume 17
Issue 7
10.3390/neurolint17070104
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Background:
Brief Report

Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study

by
Adrian Scutelnic
1,†,
Tomas Klail
2,†,
Diego Moor
1,
Nedelina Slavova
1,2,
Valentina Petroulia
2,
Simon Jung
1,
Mattia Branca
3,
Urs Fischer
1,
Franz Riederer
1,
Roland Wiest
2 and
Christoph J. Schankin
1,4,*
1
Department of Neurology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland
2
Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, 3010 Bern, Switzerland
3
CTU Bern, University of Bern, 3012 Bern, Switzerland
4
Centre for Migraine and Headache, Bellevue Medical Group, 8001 Zürich, Switzerland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Neurol. Int. 2025, 17(7), 104; https://doi.org/10.3390/neurolint17070104
Submission received: 18 May 2025 / Revised: 24 June 2025 / Accepted: 27 June 2025 / Published: 8 July 2025
(This article belongs to the Section Pain Research)
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Abstract

Background: The asymmetry of cortical veins in susceptibility weighted imaging (SWI) in MRI might be a biomarker for migraine aura and cortical spreading depression (CSD). The aim of this study was to assess in humans if SWI asymmetry can be found in patients who have migraine attacks without aura. Methods: We included patients (n = 100 per group) from the emergency room setting when they (i) presented with an acute neurological deficit or headache; (ii) had a discharge diagnosis of a migraine aura, a migraine without an aura, or neither (controls without stroke or epilepsy); and (iii) had a brain MRI with SWI in the acute setting. Results: In the migraine with aura group, SWI asymmetry was found in 26% (95% CI 18–35) compared to patients with migraine without aura (3%, [95% CI 1–8], p < 0.001) and controls 7% [95% CI 3–14], p < 0.001). There was no difference between patients with migraine without aura and controls (p = 0.19). Conclusions: The distinct SWI changes in migraine with and without aura suggest that CSD might not be involved in the pathophysiology of migraine without aura.
Keywords: migraine; aura; cortical spreading depression; headache migraine; aura; cortical spreading depression; headache

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MDPI and ACS Style

Scutelnic, A.; Klail, T.; Moor, D.; Slavova, N.; Petroulia, V.; Jung, S.; Branca, M.; Fischer, U.; Riederer, F.; Wiest, R.; et al. Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study. Neurol. Int. 2025, 17, 104. https://doi.org/10.3390/neurolint17070104

AMA Style

Scutelnic A, Klail T, Moor D, Slavova N, Petroulia V, Jung S, Branca M, Fischer U, Riederer F, Wiest R, et al. Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study. Neurology International. 2025; 17(7):104. https://doi.org/10.3390/neurolint17070104

Chicago/Turabian Style

Scutelnic, Adrian, Tomas Klail, Diego Moor, Nedelina Slavova, Valentina Petroulia, Simon Jung, Mattia Branca, Urs Fischer, Franz Riederer, Roland Wiest, and et al. 2025. "Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study" Neurology International 17, no. 7: 104. https://doi.org/10.3390/neurolint17070104

APA Style

Scutelnic, A., Klail, T., Moor, D., Slavova, N., Petroulia, V., Jung, S., Branca, M., Fischer, U., Riederer, F., Wiest, R., & Schankin, C. J. (2025). Susceptibility Weighted Imaging in Migraine with and Without Aura: A Case–Control Study. Neurology International, 17(7), 104. https://doi.org/10.3390/neurolint17070104

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