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Journal of Market Access & Health Policy (JMAHP) is published by MDPI from Volume 12 Issue 1 (2024). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Taylor & Francis.
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Article

Psychometric Validation of a Patient-Reported Single-Item Assessment of ‘Good Day Bad Day’ in a Neurogenic Orthostatic Hypotension Population Treated with Droxidopa

by
Clément François
1,*,
Nicola Germain
1,
Renata Majewska
2,
Vanessa Taieb
3,†,
L. Arthur Hewitt
4 and
Steven Kymes
5
1
Health Economics and Outcomes Research, Creativ-Ceutical, Paris, France
2
Health Economics and Outcomes Research, Creativ-Ceutical S.A, Kraków, Poland
3
Health Economics and Outcomes Research, Creativ-Ceutical, London, UK
4
Medical Affairs, Lundbeck, Deerfield, IL, USA
5
Health Economics and Outcomes Research, Lundbeck, Deerfield, IL, USA
*
Author to whom correspondence should be addressed.
†
Employee of Creativ-Ceutical at the time of validation analyses.
J. Mark. Access Health Policy 2022, 10(1), 2010961; https://doi.org/10.1080/20016689.2021.2010961
Submission received: 13 April 2021 / Revised: 18 November 2021 / Accepted: 19 November 2021 / Published: 10 January 2022

Abstract

Background: Symptoms of neurogenic orthostatic hypotension (nOH), including lightheadedness/dizziness, presyncope, syncope, and falls, can lead to impaired functional ability and reduced quality of life. Because the severity and frequency of nOH symptoms fluctuate, it may be difficult for patients to accurately quantify the effect of symptoms on their daily lives using available outcome measures. A new single-item instrument, the ‘Good Day Bad Day,’ was developed, and its psychometric validity was assessed in patients with nOH. Methods: Data from a 6-month, prospective, observational cohort study of patients with nOH who were newly initiating droxidopa treatment were used. Patients were asked to quantify the number of good and bad days in the previous 7 days and responded to other validated patient-reported outcomes instruments. The concurrent and discriminant validities and the stability of the Good Day Bad Day instrument were assessed. Results: A total of 153 patients were included in the analysis (mean [SD] age, 62.3 [17] years). Change in the number of good days moderately correlated with improvements in other patient-reported outcomes (rho value range, −0.38 to −0.61). When data were examined categorically (low vs high symptom severity), the mean number of good days was higher in subgroups representing low symptom severity across measures at 1, 3, and 6 months (all P ≤ 0.01). Conclusions: The Good Day Bad Day instrument provided good discrimination at baseline and over time and may aid in assessment of the effects of nOH symptoms on patients.
Keywords: falls; functional impairment; patient-reported outcomes; single-item instrument; symptoms; validity falls; functional impairment; patient-reported outcomes; single-item instrument; symptoms; validity

Share and Cite

MDPI and ACS Style

François, C.; Germain, N.; Majewska, R.; Taieb, V.; Hewitt, L.A.; Kymes, S. Psychometric Validation of a Patient-Reported Single-Item Assessment of ‘Good Day Bad Day’ in a Neurogenic Orthostatic Hypotension Population Treated with Droxidopa. J. Mark. Access Health Policy 2022, 10, 2010961. https://doi.org/10.1080/20016689.2021.2010961

AMA Style

François C, Germain N, Majewska R, Taieb V, Hewitt LA, Kymes S. Psychometric Validation of a Patient-Reported Single-Item Assessment of ‘Good Day Bad Day’ in a Neurogenic Orthostatic Hypotension Population Treated with Droxidopa. Journal of Market Access & Health Policy. 2022; 10(1):2010961. https://doi.org/10.1080/20016689.2021.2010961

Chicago/Turabian Style

François, Clément, Nicola Germain, Renata Majewska, Vanessa Taieb, L. Arthur Hewitt, and Steven Kymes. 2022. "Psychometric Validation of a Patient-Reported Single-Item Assessment of ‘Good Day Bad Day’ in a Neurogenic Orthostatic Hypotension Population Treated with Droxidopa" Journal of Market Access & Health Policy 10, no. 1: 2010961. https://doi.org/10.1080/20016689.2021.2010961

APA Style

François, C., Germain, N., Majewska, R., Taieb, V., Hewitt, L. A., & Kymes, S. (2022). Psychometric Validation of a Patient-Reported Single-Item Assessment of ‘Good Day Bad Day’ in a Neurogenic Orthostatic Hypotension Population Treated with Droxidopa. Journal of Market Access & Health Policy, 10(1), 2010961. https://doi.org/10.1080/20016689.2021.2010961

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