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Viruses, Volume 16, Issue 12

December 2024 - 164 articles

Cover Story: Herpes simplex virus type 1 (HSV-1) acyclovir (ACV) resistance is acquired by mutations in the viral thymidine kinase (TK) or DNA polymerase (DNApol) genes. In our previous study, in order to analyze the mutations responsible for ACV resistance using recombinant HSV-1 BAC, we obtained a HSV-1 clone that was resistant to ACV without having any mutations in the TK and DNApol genes. We extended the study of the resistant HSV-1 clone by deploying next-generation full-genome sequencing and identified a single nucleotide substitution in the UL29 gene, resulting P597L amino acid mutation in the ICP8 protein. The mutant HSV-1, constructed by introducing the P597L mutation of ICP8 protein in the original HSV-1 BAC, was also resistant to ACV. These results indicated that ICP8 might be involved in the mechanism of action of anti-herpesvirus drugs against HSV-1. View this paper
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Articles (164)

  • Brief Report
  • Open Access
1,200 Views
14 Pages
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Optimized Directed Virus Evolution to Accelerate the Generation of Oncolytic Coxsackievirus B3 Adapted to Resistant Colorectal Cancer Cells

  • Leslie Elsner,
  • Babette Dieringer,
  • Anja Geisler,
  • Maxim Girod,
  • Sophie Van Linthout,
  • Jens Kurreck and
  • Henry Fechner
Viruses2024, 16(12), 1958;https://doi.org/10.3390/v16121958

20 December 2024

Recently, we demonstrated that the oncolytic Coxsackievirus B3 (CVB3) strain PD-H can be efficiently adapted to resistant colorectal cancer cells through dose-dependent passaging in colorectal cancer cells. However, the method is time-consuming, whic...

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  • Article
  • Open Access
1 Citations
2,075 Views
15 Pages
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Phylogenetic and Pathogenic Analysis of H5N1 and H5N6 High Pathogenicity Avian Influenza Virus Isolated from Poultry Farms (Layer and Broiler Chickens) in Japan in the 2023/2024 Season

  • Hayate Nishiura,
  • Asuka Kumagai,
  • Junki Mine,
  • Yoshihiro Takadate,
  • Saki Sakuma,
  • Ryota Tsunekuni,
  • Yuko Uchida and
  • Kohtaro Miyazawa
Viruses2024, 16(12), 1956;https://doi.org/10.3390/v16121956

20 December 2024

During the 2023–2024 winter, 11 high pathogenicity avian influenza (HPAI) outbreaks caused by clade 2.3.4.4b H5N1 and H5N6 HPAI viruses were confirmed in Japanese domestic poultry among 10 prefectures (n = 10 and 1, respectively). In this study...

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  • Article
  • Open Access
4 Citations
2,648 Views
11 Pages
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Persistence of Long COVID Symptoms Two Years After SARS-CoV-2 Infection: A Prospective Longitudinal Cohort Study

  • Gili Joseph,
  • Ili Margalit,
  • Yael Weiss-Ottolenghi,
  • Carmit Rubin,
  • Havi Murad,
  • Raquel C. Gardner,
  • Noam Barda,
  • Elena Ben-Shachar,
  • Victoria Indenbaum and
  • Mayan Gilboa
  • + 4 authors
Viruses2024, 16(12), 1955;https://doi.org/10.3390/v16121955

20 December 2024

Background/Objectives: Millions of individuals worldwide continue to experience symptoms following SARS-CoV-2 infection. This study aimed to assess the prevalence and phenotype of multi-system symptoms attributed to Long COVID—including fatigue...

Full Article
  • Perspective
  • Open Access
2 Citations
1,708 Views
13 Pages
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The Temporal Order of Mixed Viral Infections Matters: Common Events That Are Neglected in Plant Viral Diseases

  • Celia de Moya-Ruiz,
  • Inmaculada Ferriol and
  • Pedro Gómez
Viruses2024, 16(12), 1954;https://doi.org/10.3390/v16121954

20 December 2024

Mixed infections of plant viruses are common in crops and represent a critical biotic factor with substantial epidemiological implications for plant viral diseases. Compared to single-virus infections, mixed infections arise from simultaneous or sequ...

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  • Article
  • Open Access
1,637 Views
16 Pages
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Genetic Diversity and Antiretroviral Resistance in HIV-1-Infected Patients Newly Diagnosed in Cabo Verde

  • Silvânia Da Veiga Leal,
  • Victor Pimentel,
  • Paloma Gonçalves,
  • Isabel Inês Monteiro de Pina Araújo,
  • Ricardo Parreira,
  • Nuno Taveira,
  • Marta Pingarilho and
  • Ana B. Abecasis
Viruses2024, 16(12), 1953;https://doi.org/10.3390/v16121953

20 December 2024

The high genetic variability of HIV-1 and the emergence of transmitted drug resistance (TDR) can impact treatment efficacy. In this study, we investigated the prevalent HIV-1 genotypes and drug-resistance-associated mutations in drug-naïve HIV-1...

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  • Article
  • Open Access
1 Citations
1,769 Views
16 Pages
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Influenza Virus Surveillance from the 1918 Influenza Pandemic to the 2020 Coronavirus Pandemic in New York State, USA

  • Kay L. Escuyer,
  • Donna L. Gowie and
  • Kirsten St. George
Viruses2024, 16(12), 1952;https://doi.org/10.3390/v16121952

20 December 2024

A historical perspective of more than one hundred years of influenza surveillance in New York State demonstrates the progression from anecdotes and case counts to next-generation sequencing and electronic database management, greatly improving pandem...

Full Article
  • Article
  • Open Access
2,279 Views
16 Pages
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A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses

  • Qinglin Kang,
  • Gege Li,
  • Yan Wu,
  • Shaoyan Wang,
  • Zhengshan Chen,
  • Xiaodong Zai,
  • Xiaoyan Pan,
  • Rong Wang,
  • Jiansheng Lu and
  • Peng Du
  • + 4 authors
Viruses2024, 16(12), 1951;https://doi.org/10.3390/v16121951

20 December 2024

The Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells. To date, no treatment has...

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  • Article
  • Open Access
1 Citations
1,999 Views
14 Pages
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High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix® Vaccine: A Cross-Sectional Study

  • Dikudila Vita,
  • Manuel Lemos,
  • Zoraima Neto,
  • Mathebula Evans,
  • Ngiambudulu M. Francisco,
  • Filomeno Fortes,
  • Ema Fernandes,
  • Celso Cunha and
  • Claudia Istrate
Viruses2024, 16(12), 1949;https://doi.org/10.3390/v16121949

20 December 2024

Rotavirus group A (RVA) is a major cause of pediatric acute gastroenteritis (AGE). Vaccination is an effective public health strategy and Angola implemented it in 2014. This hospital-based study aimed to estimate the prevalence of RVA infection and t...

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  • Article
  • Open Access
2 Citations
1,528 Views
12 Pages
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Performance of Ultrasensitive Polymerase Chain Reaction Testing for JC Polyomavirus in Cerebrospinal Fluid Compared with Pathological Diagnosis of Progressive Multifocal Leukoencephalopathy

  • Kenta Takahashi,
  • Kazuo Nakamichi,
  • Yuko Sato,
  • Harutaka Katano,
  • Hideki Hasegawa,
  • Masayuki Saijo and
  • Tadaki Suzuki
Viruses2024, 16(12), 1950;https://doi.org/10.3390/v16121950

19 December 2024

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC polyomavirus (JCPyV). Based on the clinical criteria, PML is diagnosed via polymerase chain reaction (PCR) detection of JCPyV DNA in cerebrospinal fluid (CSF...

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  • Article
  • Open Access
1,199 Views
13 Pages
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Detection of DNA Viruses in Free-Ranging Rat Populations in Hungary

  • Márton Z. Vidovszky,
  • András Surján,
  • Gábor Földvári and
  • László Egyed
Viruses2024, 16(12), 1948;https://doi.org/10.3390/v16121948

19 December 2024

To address a gap in our understanding of viral infections in epidemiologically important rat species, we aimed to detect DNA viruses from the tissues of free-ranging rat populations in Hungary. DNA viruses were identified from the parenchymal organs...

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