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Current Oncology
Volume 26
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10.3747/co.26.4707
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Article

Renal Cell Carcinoma in the Canadian Indigenous Population

by
E. C. L. Wong
1,
R. H. Breau
2,
R. Mallick
3,
L. Wood
4,
F. Pouliot
5,
N. S. Basappa
6,
S. Tanguay
7,
D. Soulières
8,
A. So
9,
D. Heng
10,
L. T. Lavallée
2,
D. Drachenberg
11 and
A. Kapoor
1,*
1
Department of Surgery, McMaster University, Hamilton, ON, Canada
2
Department of Surgery, University of Ottawa, Ottawa, ON, Canada
3
Ottawa Methods Centre, The Ottawa Hospital Research Institute, Ottawa, ON
4
Department of Medicine, Dalhousie University, Halifax, NS, Canada
5
Department of Surgery, Université Laval, Quebec City, QC, Canada
6
Department of Medicine, University of Alberta, Edmonton, AB, Canada
7
Department of Surgery, McGill University, Montreal, QC, Canada
8
Department of Surgery, Université de Montréal, Montreal, QC, Canada
9
Department of Surgery, University of British Columbia, Vancouver, BC, Canada
10
Department of Medicine, University of Calgary, Calgary, AB, Canada
11
Department of Surgery, University of Manitoba, Winnipeg, MB, Canada
 
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*
Author to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(3), 367-371; https://doi.org/10.3747/co.26.4707
Submission received: 11 March 2019 / Revised: 5 April 2019 / Accepted: 12 May 2019 / Published: 1 June 2019

Abstract

Background: Diagnosis and treatment of renal cell carcinoma (RCC) might be different in Indigenous Canadians than in non-Indigenous Canadians. In this cohort study, we compared RCC presentation and treatments in Indigenous and non-Indigenous Canadians. Methods: Patients registered in the Canadian Kidney Cancer Information System treated at 16 institutions between 2011 and 2018 were included. Baseline patient, tumour, and treatment characteristics were compared between Indigenous and non-Indigenous Canadians. The primary objective was to determine if differences in RCC stage at diagnosis were evident between the groups. The secondary objective was to determine if treatments and outcomes were different between the groups. Results: During the study period, 105 of the 4529 registered patients self-identified as Indigenous. Those patients were significantly younger at the time of clinical diagnosis (57.9 ± 11.3 years vs. 62.0 ± 12.1 years, p = 0.0006) and had a family history prevalence of RCC that was double the prevalence in the non-Indigenous patients (14% vs. 7%, p = 0.004). Clinical stage at diagnosis was similar in the two groups (p = 0.61). The disease was metastatic at presentation in 11 Indigenous Canadians (10%) and in 355 non-Indigenous Canadians (8%). Comorbid conditions that could affect the management of RCC—such as obesity, renal disease, diabetes mellitus, and smoking—were more common in Indigenous Canadians (p < 0.05). Indigenous Canadians experienced a lower rate of active surveillance (p = 0.01). Treatments and median time to treatments were similar in the two groups. Conclusions: Compared with their non-Indigenous counterparts, Indigenous Canadian patients with RCC are diagnosed at an earlier age and at a similar clinical stage. Despite higher baseline comorbid conditions, clinical outcomes are not worse for Indigenous Canadians than for non-Indigenous Canadians.
Keywords: renal cell carcinoma; Indigenous Canadians; diagnosis; treatment; outcomes renal cell carcinoma; Indigenous Canadians; diagnosis; treatment; outcomes

Share and Cite

MDPI and ACS Style

Wong, E.C.L.; Breau, R.H.; Mallick, R.; Wood, L.; Pouliot, F.; Basappa, N.S.; Tanguay, S.; Soulières, D.; So, A.; Heng, D.; et al. Renal Cell Carcinoma in the Canadian Indigenous Population. Curr. Oncol. 2019, 26, 367-371. https://doi.org/10.3747/co.26.4707

AMA Style

Wong ECL, Breau RH, Mallick R, Wood L, Pouliot F, Basappa NS, Tanguay S, Soulières D, So A, Heng D, et al. Renal Cell Carcinoma in the Canadian Indigenous Population. Current Oncology. 2019; 26(3):367-371. https://doi.org/10.3747/co.26.4707

Chicago/Turabian Style

Wong, E. C. L., R. H. Breau, R. Mallick, L. Wood, F. Pouliot, N. S. Basappa, S. Tanguay, D. Soulières, A. So, D. Heng, and et al. 2019. "Renal Cell Carcinoma in the Canadian Indigenous Population" Current Oncology 26, no. 3: 367-371. https://doi.org/10.3747/co.26.4707

APA Style

Wong, E. C. L., Breau, R. H., Mallick, R., Wood, L., Pouliot, F., Basappa, N. S., Tanguay, S., Soulières, D., So, A., Heng, D., Lavallée, L. T., Drachenberg, D., & Kapoor, A. (2019). Renal Cell Carcinoma in the Canadian Indigenous Population. Current Oncology, 26(3), 367-371. https://doi.org/10.3747/co.26.4707

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